Participatory Research to Advance Colon Cancer Prevention (PROMPT)

Study protocol for a pragmatic trial

Jamie H. Thompson, Melinda Davis, Michael C. Leo, Jennifer L. Schneider, David H. Smith, Amanda F. Petrik, Melissa Castillo, Brittany Younger, Gloria D. Coronado

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Colon cancer is the second leading cause of cancer deaths in the United States. The Participatory Research to Advance Colon Cancer Prevention (PROMPT) study is a collaboration between two research institutions and a federally qualified health center (FQHC). The study seeks to raise colon cancer screening rates using a direct-mail fecal immunochemical testing (FIT) and reminder program in an FQHC serving a predominantly Latino population in California. Methods: PROMPT is a pragmatic trial enrolling 16 clinics. The study will test automated and live prompts (i.e., alerts, reminders) to a direct-mail FIT program in two phases. In Phase I, we tailored and defined intervention components for the pilot using a community-based participatory research approach called boot camp translation. We then plan to conduct a three-arm patient-randomized comparative effectiveness trial in two pilot clinics to compare 1) automated prompts, 2) live prompts, and 3) a combination of automated plus live prompts to alert and remind patients to complete screening. In Phase II, the adapted best practice intervention will be spread to additional clinics within the FQHC (estimated population 27,000) and assessed for effectiveness. Patient and staff interviews will be conducted to explore receptivity to the program and identify barriers to implementation. Discussion: This pragmatic trial applies innovative approaches to engage diverse stakeholders and will test the effectiveness and spread of a direct-mail plus reminder program. If successful, the program will provide a model for a cost-effective method to raise colon cancer screening rates among Latino patients receiving care in FQHCs. Trial registration: National Clinical Trial (NCT) Identifier NCT03167125.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalContemporary Clinical Trials
Volume67
DOIs
StatePublished - Apr 1 2018

Fingerprint

Pragmatic Clinical Trials
Colonic Neoplasms
Postal Service
Early Detection of Cancer
Hispanic Americans
Research
Health
Community-Based Participatory Research
Practice Guidelines
Population
Cause of Death
Patient Care
Clinical Trials
Interviews
Costs and Cost Analysis
Neoplasms

Keywords

  • Boot camp translation
  • Colon cancer screening
  • Community-based participatory research
  • Fecal immunochemical test
  • Pragmatic study

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Participatory Research to Advance Colon Cancer Prevention (PROMPT) : Study protocol for a pragmatic trial. / Thompson, Jamie H.; Davis, Melinda; Leo, Michael C.; Schneider, Jennifer L.; Smith, David H.; Petrik, Amanda F.; Castillo, Melissa; Younger, Brittany; Coronado, Gloria D.

In: Contemporary Clinical Trials, Vol. 67, 01.04.2018, p. 11-15.

Research output: Contribution to journalArticle

Thompson, JH, Davis, M, Leo, MC, Schneider, JL, Smith, DH, Petrik, AF, Castillo, M, Younger, B & Coronado, GD 2018, 'Participatory Research to Advance Colon Cancer Prevention (PROMPT): Study protocol for a pragmatic trial', Contemporary Clinical Trials, vol. 67, pp. 11-15. https://doi.org/10.1016/j.cct.2018.02.001
Thompson, Jamie H. ; Davis, Melinda ; Leo, Michael C. ; Schneider, Jennifer L. ; Smith, David H. ; Petrik, Amanda F. ; Castillo, Melissa ; Younger, Brittany ; Coronado, Gloria D. / Participatory Research to Advance Colon Cancer Prevention (PROMPT) : Study protocol for a pragmatic trial. In: Contemporary Clinical Trials. 2018 ; Vol. 67. pp. 11-15.
@article{e007388e01d1445185a62f1aed56e557,
title = "Participatory Research to Advance Colon Cancer Prevention (PROMPT): Study protocol for a pragmatic trial",
abstract = "Background: Colon cancer is the second leading cause of cancer deaths in the United States. The Participatory Research to Advance Colon Cancer Prevention (PROMPT) study is a collaboration between two research institutions and a federally qualified health center (FQHC). The study seeks to raise colon cancer screening rates using a direct-mail fecal immunochemical testing (FIT) and reminder program in an FQHC serving a predominantly Latino population in California. Methods: PROMPT is a pragmatic trial enrolling 16 clinics. The study will test automated and live prompts (i.e., alerts, reminders) to a direct-mail FIT program in two phases. In Phase I, we tailored and defined intervention components for the pilot using a community-based participatory research approach called boot camp translation. We then plan to conduct a three-arm patient-randomized comparative effectiveness trial in two pilot clinics to compare 1) automated prompts, 2) live prompts, and 3) a combination of automated plus live prompts to alert and remind patients to complete screening. In Phase II, the adapted best practice intervention will be spread to additional clinics within the FQHC (estimated population 27,000) and assessed for effectiveness. Patient and staff interviews will be conducted to explore receptivity to the program and identify barriers to implementation. Discussion: This pragmatic trial applies innovative approaches to engage diverse stakeholders and will test the effectiveness and spread of a direct-mail plus reminder program. If successful, the program will provide a model for a cost-effective method to raise colon cancer screening rates among Latino patients receiving care in FQHCs. Trial registration: National Clinical Trial (NCT) Identifier NCT03167125.",
keywords = "Boot camp translation, Colon cancer screening, Community-based participatory research, Fecal immunochemical test, Pragmatic study",
author = "Thompson, {Jamie H.} and Melinda Davis and Leo, {Michael C.} and Schneider, {Jennifer L.} and Smith, {David H.} and Petrik, {Amanda F.} and Melissa Castillo and Brittany Younger and Coronado, {Gloria D.}",
year = "2018",
month = "4",
day = "1",
doi = "10.1016/j.cct.2018.02.001",
language = "English (US)",
volume = "67",
pages = "11--15",
journal = "Contemporary Clinical Trials",
issn = "1551-7144",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Participatory Research to Advance Colon Cancer Prevention (PROMPT)

T2 - Study protocol for a pragmatic trial

AU - Thompson, Jamie H.

AU - Davis, Melinda

AU - Leo, Michael C.

AU - Schneider, Jennifer L.

AU - Smith, David H.

AU - Petrik, Amanda F.

AU - Castillo, Melissa

AU - Younger, Brittany

AU - Coronado, Gloria D.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background: Colon cancer is the second leading cause of cancer deaths in the United States. The Participatory Research to Advance Colon Cancer Prevention (PROMPT) study is a collaboration between two research institutions and a federally qualified health center (FQHC). The study seeks to raise colon cancer screening rates using a direct-mail fecal immunochemical testing (FIT) and reminder program in an FQHC serving a predominantly Latino population in California. Methods: PROMPT is a pragmatic trial enrolling 16 clinics. The study will test automated and live prompts (i.e., alerts, reminders) to a direct-mail FIT program in two phases. In Phase I, we tailored and defined intervention components for the pilot using a community-based participatory research approach called boot camp translation. We then plan to conduct a three-arm patient-randomized comparative effectiveness trial in two pilot clinics to compare 1) automated prompts, 2) live prompts, and 3) a combination of automated plus live prompts to alert and remind patients to complete screening. In Phase II, the adapted best practice intervention will be spread to additional clinics within the FQHC (estimated population 27,000) and assessed for effectiveness. Patient and staff interviews will be conducted to explore receptivity to the program and identify barriers to implementation. Discussion: This pragmatic trial applies innovative approaches to engage diverse stakeholders and will test the effectiveness and spread of a direct-mail plus reminder program. If successful, the program will provide a model for a cost-effective method to raise colon cancer screening rates among Latino patients receiving care in FQHCs. Trial registration: National Clinical Trial (NCT) Identifier NCT03167125.

AB - Background: Colon cancer is the second leading cause of cancer deaths in the United States. The Participatory Research to Advance Colon Cancer Prevention (PROMPT) study is a collaboration between two research institutions and a federally qualified health center (FQHC). The study seeks to raise colon cancer screening rates using a direct-mail fecal immunochemical testing (FIT) and reminder program in an FQHC serving a predominantly Latino population in California. Methods: PROMPT is a pragmatic trial enrolling 16 clinics. The study will test automated and live prompts (i.e., alerts, reminders) to a direct-mail FIT program in two phases. In Phase I, we tailored and defined intervention components for the pilot using a community-based participatory research approach called boot camp translation. We then plan to conduct a three-arm patient-randomized comparative effectiveness trial in two pilot clinics to compare 1) automated prompts, 2) live prompts, and 3) a combination of automated plus live prompts to alert and remind patients to complete screening. In Phase II, the adapted best practice intervention will be spread to additional clinics within the FQHC (estimated population 27,000) and assessed for effectiveness. Patient and staff interviews will be conducted to explore receptivity to the program and identify barriers to implementation. Discussion: This pragmatic trial applies innovative approaches to engage diverse stakeholders and will test the effectiveness and spread of a direct-mail plus reminder program. If successful, the program will provide a model for a cost-effective method to raise colon cancer screening rates among Latino patients receiving care in FQHCs. Trial registration: National Clinical Trial (NCT) Identifier NCT03167125.

KW - Boot camp translation

KW - Colon cancer screening

KW - Community-based participatory research

KW - Fecal immunochemical test

KW - Pragmatic study

UR - http://www.scopus.com/inward/record.url?scp=85041505669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041505669&partnerID=8YFLogxK

U2 - 10.1016/j.cct.2018.02.001

DO - 10.1016/j.cct.2018.02.001

M3 - Article

VL - 67

SP - 11

EP - 15

JO - Contemporary Clinical Trials

JF - Contemporary Clinical Trials

SN - 1551-7144

ER -