Partial Recovery of Brain Metabolism in Methamphetamine Abusers after Protracted Abstinence

Gene Jack Wang, Nora D. Volkow, Linda Chang, Eric Miller, Mark Sedler, Robert Hitzemann, Wei Zhu, Jean Logan, Yeming Ma, Joanna S. Fowler

Research output: Contribution to journalArticle

174 Scopus citations


Objective: Methamphetamine is a highly addictive drug of abuse that is neurotoxic to dopamine terminals. The authors recently reported that decreases in dopamine transporters (used as markers of dopamine terminals) in the striatum of methamphetamine abusers recover with protracted abstinence and that relative to comparison subjects, recently detoxified methamphetamine abusers have lower metabolism in the striatum and thalamus. In this study, the authors assessed whether metabolism recovers with protracted abstinence. Method: Brain glucose metabolism was measured with positron emission tomography and [ 18F]fluorodeoxyglucose in five methamphetamine abusers who were evaluated after both a short (

Original languageEnglish (US)
Pages (from-to)242-248
Number of pages7
JournalAmerican Journal of Psychiatry
Issue number2
Publication statusPublished - Feb 2004
Externally publishedYes


ASJC Scopus subject areas

  • Psychiatry and Mental health

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