Parsing the undercontrol-disinhibition pathway to substance use disorders: A multilevel developmental problem

Robert A. Zucker, Mary M. Heitzeg, Joel Nigg

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

A long-standing and diverse body of evidence has documented the importance of externalizing characteristics as very early etiologic predictors of a pathway to severe alcohol and other drug problems and substance use disorder (SUD). At the same time, much remains unclear about the mechanistic structure of this pathway, including understanding what the defining characteristics are that encompass the diverse behaviors included in the externalizing domain. This article proposes that the core risk phenotype unifying this domain is behavioral undercontrol-disinhibition. It describes the defining features of this phenotype and outlines the mediators, moderators, and developmental course that characterize the pathway from early risk to a SUD endpoint. A brief summary of the neurocognitive and brain functional response systems that underlie the behavioral phenotype emphasizes the operation of two systems in dynamic tension, one an effortful control system, the other an incentive reactivity system.

Original languageEnglish (US)
Pages (from-to)248-255
Number of pages8
JournalChild Development Perspectives
Volume5
Issue number4
DOIs
StatePublished - Dec 2011

Fingerprint

Substance-Related Disorders
Phenotype
drug problem
moderator
control system
Motivation
brain
alcohol
incentive
Alcohols
Brain
evidence

Keywords

  • Effortful control
  • Externalizing behavior
  • Impulsivity
  • Incentive reactivity
  • Risk phenotype

ASJC Scopus subject areas

  • Life-span and Life-course Studies
  • Developmental and Educational Psychology
  • Pediatrics, Perinatology, and Child Health

Cite this

Parsing the undercontrol-disinhibition pathway to substance use disorders : A multilevel developmental problem. / Zucker, Robert A.; Heitzeg, Mary M.; Nigg, Joel.

In: Child Development Perspectives, Vol. 5, No. 4, 12.2011, p. 248-255.

Research output: Contribution to journalArticle

@article{5bdb117fc5f840a7ae2ddb9b5037aa3a,
title = "Parsing the undercontrol-disinhibition pathway to substance use disorders: A multilevel developmental problem",
abstract = "A long-standing and diverse body of evidence has documented the importance of externalizing characteristics as very early etiologic predictors of a pathway to severe alcohol and other drug problems and substance use disorder (SUD). At the same time, much remains unclear about the mechanistic structure of this pathway, including understanding what the defining characteristics are that encompass the diverse behaviors included in the externalizing domain. This article proposes that the core risk phenotype unifying this domain is behavioral undercontrol-disinhibition. It describes the defining features of this phenotype and outlines the mediators, moderators, and developmental course that characterize the pathway from early risk to a SUD endpoint. A brief summary of the neurocognitive and brain functional response systems that underlie the behavioral phenotype emphasizes the operation of two systems in dynamic tension, one an effortful control system, the other an incentive reactivity system.",
keywords = "Effortful control, Externalizing behavior, Impulsivity, Incentive reactivity, Risk phenotype",
author = "Zucker, {Robert A.} and Heitzeg, {Mary M.} and Joel Nigg",
year = "2011",
month = "12",
doi = "10.1111/j.1750-8606.2011.00172.x",
language = "English (US)",
volume = "5",
pages = "248--255",
journal = "Child Development Perspectives",
issn = "1750-8592",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Parsing the undercontrol-disinhibition pathway to substance use disorders

T2 - A multilevel developmental problem

AU - Zucker, Robert A.

AU - Heitzeg, Mary M.

AU - Nigg, Joel

PY - 2011/12

Y1 - 2011/12

N2 - A long-standing and diverse body of evidence has documented the importance of externalizing characteristics as very early etiologic predictors of a pathway to severe alcohol and other drug problems and substance use disorder (SUD). At the same time, much remains unclear about the mechanistic structure of this pathway, including understanding what the defining characteristics are that encompass the diverse behaviors included in the externalizing domain. This article proposes that the core risk phenotype unifying this domain is behavioral undercontrol-disinhibition. It describes the defining features of this phenotype and outlines the mediators, moderators, and developmental course that characterize the pathway from early risk to a SUD endpoint. A brief summary of the neurocognitive and brain functional response systems that underlie the behavioral phenotype emphasizes the operation of two systems in dynamic tension, one an effortful control system, the other an incentive reactivity system.

AB - A long-standing and diverse body of evidence has documented the importance of externalizing characteristics as very early etiologic predictors of a pathway to severe alcohol and other drug problems and substance use disorder (SUD). At the same time, much remains unclear about the mechanistic structure of this pathway, including understanding what the defining characteristics are that encompass the diverse behaviors included in the externalizing domain. This article proposes that the core risk phenotype unifying this domain is behavioral undercontrol-disinhibition. It describes the defining features of this phenotype and outlines the mediators, moderators, and developmental course that characterize the pathway from early risk to a SUD endpoint. A brief summary of the neurocognitive and brain functional response systems that underlie the behavioral phenotype emphasizes the operation of two systems in dynamic tension, one an effortful control system, the other an incentive reactivity system.

KW - Effortful control

KW - Externalizing behavior

KW - Impulsivity

KW - Incentive reactivity

KW - Risk phenotype

UR - http://www.scopus.com/inward/record.url?scp=80053502152&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053502152&partnerID=8YFLogxK

U2 - 10.1111/j.1750-8606.2011.00172.x

DO - 10.1111/j.1750-8606.2011.00172.x

M3 - Article

AN - SCOPUS:80053502152

VL - 5

SP - 248

EP - 255

JO - Child Development Perspectives

JF - Child Development Perspectives

SN - 1750-8592

IS - 4

ER -