Parkinson's disease is associated with hippocampal atrophy

Richard Camicioli, M. Milar Moore, Anthony Kinney, Elizabeth Corbridge, Kathryn Glassberg, Jeffrey Kaye

Research output: Contribution to journalArticle

218 Citations (Scopus)

Abstract

Patients with Parkinson's disease (PD) may have hippocampal atrophy compared with controls. We compared hippocampal, and extra-hippocampal volumes between PD, PDD (patients with PD who have mild cognitive impairment or dementia), Alzheimer's disease (AD) and controls using volumetric magnetic resonance imaging (MRI). Participants (10 patients with PD, 10 with PDD, 11 with AD, and 12 control subjects) had an informant interview, neurological examination, and psychometric testing. Established, reliable methods were used to measure the hippocampus, parahippocampal gyrus, temporal, frontal, and parieto-occipital lobes. Correction for intracranial volume was carried out before comparison. There was no age difference between groups (mean age, 74 years). On the Clinical Dementia Rating scale (CDR) cognitive impairment was mild (CDR = 0.5) in the majority of PDD and AD patients. Hippocampal (P <0.0004) volumes were smaller in the patient groups. Effect sizes compared with the control group were: PD, 0.66; PDD, 1.22; and AD, 1.81. The other volumes did not differ significantly. Among PD, and PDD patients, recognition memory (r = 0.54, P = 0.015) and Mini-Mental State Examination scores (r = 0.56, P = 0.01) correlated with left, but not right hippocampal volume. In conclusion, hippocampal volume showed a pattern (Control > PD > PDD > AD) suggesting progressive hippocampal volume loss in PD. Volumetric MRI imaging might provide an early maker for dementia in PD.

Original languageEnglish (US)
Pages (from-to)784-790
Number of pages7
JournalMovement Disorders
Volume18
Issue number7
DOIs
StatePublished - Jul 1 2003

Fingerprint

Atrophy
Parkinson Disease
Dementia
Alzheimer Disease
Magnetic Resonance Imaging
Occipital Lobe
Parahippocampal Gyrus
Neurologic Examination
Psychometrics
Hippocampus
Age Groups
Interviews
Cognitive Dysfunction

Keywords

  • Alzheimer's disease
  • Atrophy
  • Dementia
  • Hippocampus
  • MRI
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Camicioli, R., Moore, M. M., Kinney, A., Corbridge, E., Glassberg, K., & Kaye, J. (2003). Parkinson's disease is associated with hippocampal atrophy. Movement Disorders, 18(7), 784-790. https://doi.org/10.1002/mds.10444

Parkinson's disease is associated with hippocampal atrophy. / Camicioli, Richard; Moore, M. Milar; Kinney, Anthony; Corbridge, Elizabeth; Glassberg, Kathryn; Kaye, Jeffrey.

In: Movement Disorders, Vol. 18, No. 7, 01.07.2003, p. 784-790.

Research output: Contribution to journalArticle

Camicioli, R, Moore, MM, Kinney, A, Corbridge, E, Glassberg, K & Kaye, J 2003, 'Parkinson's disease is associated with hippocampal atrophy', Movement Disorders, vol. 18, no. 7, pp. 784-790. https://doi.org/10.1002/mds.10444
Camicioli R, Moore MM, Kinney A, Corbridge E, Glassberg K, Kaye J. Parkinson's disease is associated with hippocampal atrophy. Movement Disorders. 2003 Jul 1;18(7):784-790. https://doi.org/10.1002/mds.10444
Camicioli, Richard ; Moore, M. Milar ; Kinney, Anthony ; Corbridge, Elizabeth ; Glassberg, Kathryn ; Kaye, Jeffrey. / Parkinson's disease is associated with hippocampal atrophy. In: Movement Disorders. 2003 ; Vol. 18, No. 7. pp. 784-790.
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