Parkinson's disease

Ali Samii, John G. Nutt, Bruce R. Ransom

Research output: Contribution to journalArticle

754 Scopus citations

Abstract

Parkinson's disease is the most common serious movement disorder in the world, affecting about 1% of adults older than 60 years. The disease is attributed to selective loss of neurons in the substantia nigra, and its cause is enigmatic in most individuals. Symptoms of Parkinson's disease respond in varying degrees to drugs, and surgery offers hope for patients no longer adequately controlled in this manner. The high prevalence of the disease, and important advances in its management, mean that generalists need to have a working knowledge of this disorder. This Seminar covers the basics, from terminology to aspects of diagnosis, treatment, and pathogenesis.

Original languageEnglish (US)
Pages (from-to)1783-1793
Number of pages11
JournalLancet
Volume363
Issue number9423
DOIs
StatePublished - May 29 2004

ASJC Scopus subject areas

  • Medicine(all)

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    Samii, A., Nutt, J. G., & Ransom, B. R. (2004). Parkinson's disease. Lancet, 363(9423), 1783-1793. https://doi.org/10.1016/S0140-6736(04)16305-8