Pargyline reduces/prevents neuroleptic-induced acute dystonia in monkeys

R. Heintz, Daniel Casey

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The neuropharmacologic mechanisms underlying neuroleptic-induced extrapyramidal syndromes (EPS) were studied using a nonhuman primate model. Twenty-six Cebus albifrons monkeys were given weekly challenges of haloperidol (0.025 mg/kg IM), and half of the animals received the monoamine oxidase (MAO) inhibitor pargyline (5 mg/kg PO) daily for 17 consecutive days during the protocol. Pargyline caused no changes in baseline behaviors, but significantly reduced haloperidol-induced acute dystonia (AD) (-67%, P

Original languageEnglish (US)
Pages (from-to)207-213
Number of pages7
JournalPsychopharmacology
Volume93
Issue number2
DOIs
Publication statusPublished - Oct 1987

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Keywords

  • Cebus albifrons monkeys
  • Dystonia
  • Extrapyramidal syndromes
  • Monoamine oxidase
  • Neuroleptics
  • Pargyline
  • Primates

ASJC Scopus subject areas

  • Pharmacology

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