Parenteral feeding alters the fatty acid composition of serum phospholipids of rabbits

R. Lawrence Moss, T. Miko Enomoto, Allan Haynes, Donald E. Fry, Robert H. Glew

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Cholestatic liver disease develops in 30% to 70% of neonates receiving total parenteral nutrition (TPN). We analyzed the fatty acid composition of serum phospholipids from control and TPN-fed rabbits to determine if TPN altered the fatty acid profile. Methods: Eleven male New Zealand White rabbits aged 9 to 11 weeks received TPN, whereas 11 other rabbits were offered standard laboratory rabbit chow ad libitum. After 14 days on the prescribed diet, serum samples were analyzed for their phospholipid fatty acid content by gas chromatography. Results: The proportions of palmitolenic (16:2n7), α-linolenic (18:3n3), arachidic (20:0), and eicosaenoic (20:1n9) acids were significantly lower in the serum phospholipids of the TPN-fed animals compared with the control group. The proportion of docosahexaenoic acid (22:6n3), a fatty acid that is critical to the development of the nervous system, was increased two- to threefold. Conclusions: The differences in proportions of fatty acids observed between control and TPN-fed animals indicate that fatty acid elongation and desaturation pathways are perturbed in rabbits on TPN.

Original languageEnglish (US)
Pages (from-to)98-101
Number of pages4
JournalJournal of Parenteral and Enteral Nutrition
Volume22
Issue number2
DOIs
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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