Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain

Vinita Rangroo Thrane, Alexander S. Thrane, Benjamin A. Plog, Meenakshisundaram Thiyagarajan, Jeffrey J. Iliff, Rashid Deane, Erlend A. Nagelhus, Maiken Nedergaard

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79 Scopus citations

Abstract

In the brain, a paravascular space exists between vascular cells and astroglial end-foot processes, creating a continuous sheath surrounding blood vessels. Using in vivo two-photon imaging we demonstrate that the paravascular circulation facilitates selective transport of small lipophilic molecules, rapid interstitial fluid movement and widespread glial calcium signaling. Depressurizing the paravascular system leads to unselective lipid diffusion, intracellular lipid accumulation and pathological signaling in astrocytes. As the central nervous system is devoid of lymphatic vessels, the paravascular space may serve as a lymphatic equivalent that represents a separate highway for the transport of lipids and signaling molecules.

Original languageEnglish (US)
Article number2582
JournalScientific Reports
Volume3
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • General

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    Thrane, V. R., Thrane, A. S., Plog, B. A., Thiyagarajan, M., Iliff, J. J., Deane, R., Nagelhus, E. A., & Nedergaard, M. (2013). Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain. Scientific Reports, 3, [2582]. https://doi.org/10.1038/srep02582