Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain

Vinita Rangroo Thrane, Alexander S. Thrane, Benjamin A. Plog, Meenakshisundaram Thiyagarajan, Jeffrey Iliff, Rashid Deane, Erlend A. Nagelhus, Maiken Nedergaard

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

In the brain, a paravascular space exists between vascular cells and astroglial end-foot processes, creating a continuous sheath surrounding blood vessels. Using in vivo two-photon imaging we demonstrate that the paravascular circulation facilitates selective transport of small lipophilic molecules, rapid interstitial fluid movement and widespread glial calcium signaling. Depressurizing the paravascular system leads to unselective lipid diffusion, intracellular lipid accumulation and pathological signaling in astrocytes. As the central nervous system is devoid of lymphatic vessels, the paravascular space may serve as a lymphatic equivalent that represents a separate highway for the transport of lipids and signaling molecules.

Original languageEnglish (US)
Article number2582
JournalScientific Reports
Volume3
DOIs
StatePublished - 2013
Externally publishedYes

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Microcirculation
Astrocytes
Lipids
Blood Vessels
Brain
Lymphatic Vessels
Calcium Signaling
Extracellular Fluid
Photons
Neuroglia
Central Nervous System

ASJC Scopus subject areas

  • General

Cite this

Thrane, V. R., Thrane, A. S., Plog, B. A., Thiyagarajan, M., Iliff, J., Deane, R., ... Nedergaard, M. (2013). Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain. Scientific Reports, 3, [2582]. https://doi.org/10.1038/srep02582

Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain. / Thrane, Vinita Rangroo; Thrane, Alexander S.; Plog, Benjamin A.; Thiyagarajan, Meenakshisundaram; Iliff, Jeffrey; Deane, Rashid; Nagelhus, Erlend A.; Nedergaard, Maiken.

In: Scientific Reports, Vol. 3, 2582, 2013.

Research output: Contribution to journalArticle

Thrane, VR, Thrane, AS, Plog, BA, Thiyagarajan, M, Iliff, J, Deane, R, Nagelhus, EA & Nedergaard, M 2013, 'Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain', Scientific Reports, vol. 3, 2582. https://doi.org/10.1038/srep02582
Thrane, Vinita Rangroo ; Thrane, Alexander S. ; Plog, Benjamin A. ; Thiyagarajan, Meenakshisundaram ; Iliff, Jeffrey ; Deane, Rashid ; Nagelhus, Erlend A. ; Nedergaard, Maiken. / Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain. In: Scientific Reports. 2013 ; Vol. 3.
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