Paraneoplastic Vitelliform Retinopathy

Clinicopathologic Correlation and Review of the Literature

Mary E. Aronow, Grazyna Adamus, Mones Abu-Asab, Yujuan Wang, Chi Chao Chan, Z. Nicholas Zakov, Arun D. Singh

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Traditionally, the paraneoplastic retinopathies have been classified into two groups: melanoma-associated retinopathy (MAR) and cancer-associated retinopathy. MAR occurs in individuals with metastatic cutaneous or uveal melanoma and is characterized by nyctalopia, photopsias, and variable vision loss. In most cases, the fundus is essentially normal in appearance. More recently, there have been multiple reports of a MAR-like retinopathy with associated detachments of the retinal pigment epithelium and neurosensory retina. Such a clinical presentation has been termed paraneoplastic vitelliform retinopathy. We describe an 80-year-old man with metastatic cutaneous melanoma who developed paraneoplastic vitelliform retinopathy. For the first time, histopathology from enucleation specimens provides a clinicopathologic disease correlation with focal abnormalities in the inner nuclear and outer plexiform layers.

Original languageEnglish (US)
Pages (from-to)558-564
Number of pages7
JournalSurvey of Ophthalmology
Volume57
Issue number6
DOIs
StatePublished - Nov 2012

Fingerprint

Ocular Paraneoplastic Syndromes
Night Blindness
Skin
Retinal Pigment Epithelium
Retina
Melanoma

Keywords

  • Autoantibodies
  • Autoimmune
  • CAR
  • Cutaneous
  • MAR
  • Melanoma
  • Paraneoplastic vitelliform retinopathy
  • Retina
  • Retinopathy
  • Uveal

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Paraneoplastic Vitelliform Retinopathy : Clinicopathologic Correlation and Review of the Literature. / Aronow, Mary E.; Adamus, Grazyna; Abu-Asab, Mones; Wang, Yujuan; Chan, Chi Chao; Zakov, Z. Nicholas; Singh, Arun D.

In: Survey of Ophthalmology, Vol. 57, No. 6, 11.2012, p. 558-564.

Research output: Contribution to journalArticle

Aronow, Mary E. ; Adamus, Grazyna ; Abu-Asab, Mones ; Wang, Yujuan ; Chan, Chi Chao ; Zakov, Z. Nicholas ; Singh, Arun D. / Paraneoplastic Vitelliform Retinopathy : Clinicopathologic Correlation and Review of the Literature. In: Survey of Ophthalmology. 2012 ; Vol. 57, No. 6. pp. 558-564.
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