Parametric imaging of cancer with optical coherence tomography

Robert A. McLaughlin, Loretta Scolaro, Peter Robbins, Christobel Saunders, Steven Jacques, David D. Sampson

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

We present a parametric optical coherence tomography (OCT) technique to improve contrast between malignant and healthy non-neoplastic tissue. The technique incorporates a fully automated method to extract tissue attenuation characteristics. Results are represented visually as a parametric en face image, where the parameter used for contrast is indicative of the relative optical attenuation coefficient of the tissue. We present the first parametric OCT images of human lymph nodes containing malignant cells, and demonstrate improved tissue contrast over en face OCT images.

Original languageEnglish (US)
Article number046029
JournalJournal of Biomedical Optics
Volume15
Issue number4
DOIs
StatePublished - Jul 2010

Fingerprint

Optical tomography
tomography
cancer
Tissue
Imaging techniques
Tissue Extracts
lymphatic system
attenuation coefficients
attenuation
cells

Keywords

  • Cancer
  • Lymph node
  • Optical coherence tomography
  • Parametric imaging
  • Parametric optical coherence tomography

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

McLaughlin, R. A., Scolaro, L., Robbins, P., Saunders, C., Jacques, S., & Sampson, D. D. (2010). Parametric imaging of cancer with optical coherence tomography. Journal of Biomedical Optics, 15(4), [046029]. https://doi.org/10.1117/1.3479931

Parametric imaging of cancer with optical coherence tomography. / McLaughlin, Robert A.; Scolaro, Loretta; Robbins, Peter; Saunders, Christobel; Jacques, Steven; Sampson, David D.

In: Journal of Biomedical Optics, Vol. 15, No. 4, 046029, 07.2010.

Research output: Contribution to journalArticle

McLaughlin, RA, Scolaro, L, Robbins, P, Saunders, C, Jacques, S & Sampson, DD 2010, 'Parametric imaging of cancer with optical coherence tomography', Journal of Biomedical Optics, vol. 15, no. 4, 046029. https://doi.org/10.1117/1.3479931
McLaughlin RA, Scolaro L, Robbins P, Saunders C, Jacques S, Sampson DD. Parametric imaging of cancer with optical coherence tomography. Journal of Biomedical Optics. 2010 Jul;15(4). 046029. https://doi.org/10.1117/1.3479931
McLaughlin, Robert A. ; Scolaro, Loretta ; Robbins, Peter ; Saunders, Christobel ; Jacques, Steven ; Sampson, David D. / Parametric imaging of cancer with optical coherence tomography. In: Journal of Biomedical Optics. 2010 ; Vol. 15, No. 4.
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