Abstract
We present a parametric optical coherence tomography (OCT) technique to improve contrast between malignant and healthy non-neoplastic tissue. The technique incorporates a fully automated method to extract tissue attenuation characteristics. Results are represented visually as a parametric en face image, where the parameter used for contrast is indicative of the relative optical attenuation coefficient of the tissue. We present the first parametric OCT images of human lymph nodes containing malignant cells, and demonstrate improved tissue contrast over en face OCT images.
Original language | English (US) |
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Article number | 046029 |
Journal | Journal of biomedical optics |
Volume | 15 |
Issue number | 4 |
DOIs | |
State | Published - Jul 2010 |
Externally published | Yes |
Keywords
- Cancer
- Lymph node
- Optical coherence tomography
- Parametric imaging
- Parametric optical coherence tomography
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Biomedical Engineering