Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging

N. D. Volkow, G. J. Wang, J. S. Fowler, Y. S. Ding, R. C. Gur, J. Gatley, J. Logan, P. J. Moberg, Robert Hitzemann, G. Smith, N. Pappas

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Positron emission tomography studies revealed that in healthy individuals, the age-related losses in DA transporters (presynaptic marker) were associated with losses in D2 receptors (postsynaptic marker) rather than with increases as is known to occur with DA cell loss. This association was specific for DA synaptic markers, because they were not correlated with striatal metabolism. Furthermore, the association was independent of age, suggesting that a common mechanism regulates the expression of receptors and transporters irrespective of age.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalAnnals of Neurology
Volume44
Issue number1
DOIs
StatePublished - Jul 1998
Externally publishedYes

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Dopamine
Corpus Striatum
Dopamine Plasma Membrane Transport Proteins
Positron-Emission Tomography
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Volkow, N. D., Wang, G. J., Fowler, J. S., Ding, Y. S., Gur, R. C., Gatley, J., ... Pappas, N. (1998). Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging. Annals of Neurology, 44(1), 143-147. https://doi.org/10.1002/ana.410440125

Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging. / Volkow, N. D.; Wang, G. J.; Fowler, J. S.; Ding, Y. S.; Gur, R. C.; Gatley, J.; Logan, J.; Moberg, P. J.; Hitzemann, Robert; Smith, G.; Pappas, N.

In: Annals of Neurology, Vol. 44, No. 1, 07.1998, p. 143-147.

Research output: Contribution to journalArticle

Volkow, ND, Wang, GJ, Fowler, JS, Ding, YS, Gur, RC, Gatley, J, Logan, J, Moberg, PJ, Hitzemann, R, Smith, G & Pappas, N 1998, 'Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging', Annals of Neurology, vol. 44, no. 1, pp. 143-147. https://doi.org/10.1002/ana.410440125
Volkow ND, Wang GJ, Fowler JS, Ding YS, Gur RC, Gatley J et al. Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging. Annals of Neurology. 1998 Jul;44(1):143-147. https://doi.org/10.1002/ana.410440125
Volkow, N. D. ; Wang, G. J. ; Fowler, J. S. ; Ding, Y. S. ; Gur, R. C. ; Gatley, J. ; Logan, J. ; Moberg, P. J. ; Hitzemann, Robert ; Smith, G. ; Pappas, N. / Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging. In: Annals of Neurology. 1998 ; Vol. 44, No. 1. pp. 143-147.
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