Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging

N. D. Volkow, G. J. Wang, J. S. Fowler, Y. S. Ding, R. C. Gur, J. Gatley, J. Logan, P. J. Moberg, R. Hitzemann, G. Smith, N. Pappas

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Abstract

Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Positron emission tomography studies revealed that in healthy individuals, the age-related losses in DA transporters (presynaptic marker) were associated with losses in D2 receptors (postsynaptic marker) rather than with increases as is known to occur with DA cell loss. This association was specific for DA synaptic markers, because they were not correlated with striatal metabolism. Furthermore, the association was independent of age, suggesting that a common mechanism regulates the expression of receptors and transporters irrespective of age.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalAnnals of Neurology
Volume44
Issue number1
DOIs
StatePublished - Jul 1 1998

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Volkow, N. D., Wang, G. J., Fowler, J. S., Ding, Y. S., Gur, R. C., Gatley, J., Logan, J., Moberg, P. J., Hitzemann, R., Smith, G., & Pappas, N. (1998). Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging. Annals of Neurology, 44(1), 143-147. https://doi.org/10.1002/ana.410440125