Parafoveal retinal vascular response to pattern visual stimulation assessed with OCT angiography

Eric Wei, Jia Yali, Ou Tan, Benjamin Potsaid, Jonathan J. Liu, Woo Jhon Choi, James G. Fujimoto, David Huang

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

We used optical coherence tomography (OCT) angiography with a high-speed swept-source OCT system to investigate retinal blood flow changes induced by visual stimulation with a reversing checkerboard pattern. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to quantify blood flow as measured with parafoveal flow index (PFI), which is proportional to the density of blood vessels and the velocity of blood flow in the parafoveal region of the macula. PFI measurements were taken in 15 second intervals during a 4 minute period consisting of 1 minute of baseline, 2 minutes with an 8 Hz reversing checkerboard pattern stimulation, and 1 minute without stimulation. PFI measurements increased 6.1±4.7% (p = .001) during the first minute of stimulation, with the most significant increase in PFI occurring 30 seconds into stimulation (p

Original languageEnglish (US)
Article numbere81343
JournalPLoS One
Volume8
Issue number12
DOIs
StatePublished - Dec 2 2013

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Retinal Vessels
Photic Stimulation
Angiography
Optical tomography
tomography
Optical Coherence Tomography
blood vessels
Blood
blood flow
Blood Flow Velocity
Blood Vessels
Blood vessels

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Parafoveal retinal vascular response to pattern visual stimulation assessed with OCT angiography. / Wei, Eric; Yali, Jia; Tan, Ou; Potsaid, Benjamin; Liu, Jonathan J.; Choi, Woo Jhon; Fujimoto, James G.; Huang, David.

In: PLoS One, Vol. 8, No. 12, e81343, 02.12.2013.

Research output: Contribution to journalArticle

Wei, Eric ; Yali, Jia ; Tan, Ou ; Potsaid, Benjamin ; Liu, Jonathan J. ; Choi, Woo Jhon ; Fujimoto, James G. ; Huang, David. / Parafoveal retinal vascular response to pattern visual stimulation assessed with OCT angiography. In: PLoS One. 2013 ; Vol. 8, No. 12.
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