Paradoxical roles of the immune system during cancer development

Karin E. De Visser, Alexandra Eichten, Lisa Coussens

Research output: Contribution to journalArticle

1415 Citations (Scopus)

Abstract

The main function of the mammalian immune system is to monitor tissue homeostasis, to protect against invading or infectious pathogens and to eliminate damaged cells. Therefore, it is surprising that cancer occurs with such a high frequency in humans. Recent insights that have been gained from clinical studies and experimental mouse models of carcinogenesis expand our understanding of the complex relationship between immune cells and developing tumours. Here, we examine the paradoxical role of adaptive and innate leukocytes as crucial regulators of cancer development and highlight recent insights that have been gained by manipulating immune responses in mouse models of de novo and spontaneous tumorigenesis.

Original languageEnglish (US)
Pages (from-to)24-37
Number of pages14
JournalNature Reviews Cancer
Volume6
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

Fingerprint

Immune System
Carcinogenesis
Neoplasms
Leukocytes
Homeostasis
Theoretical Models
Clinical Studies

ASJC Scopus subject areas

  • Cancer Research

Cite this

Paradoxical roles of the immune system during cancer development. / De Visser, Karin E.; Eichten, Alexandra; Coussens, Lisa.

In: Nature Reviews Cancer, Vol. 6, No. 1, 01.2006, p. 24-37.

Research output: Contribution to journalArticle

De Visser, Karin E. ; Eichten, Alexandra ; Coussens, Lisa. / Paradoxical roles of the immune system during cancer development. In: Nature Reviews Cancer. 2006 ; Vol. 6, No. 1. pp. 24-37.
@article{7153c26e01df4df28d82bf13029213bf,
title = "Paradoxical roles of the immune system during cancer development",
abstract = "The main function of the mammalian immune system is to monitor tissue homeostasis, to protect against invading or infectious pathogens and to eliminate damaged cells. Therefore, it is surprising that cancer occurs with such a high frequency in humans. Recent insights that have been gained from clinical studies and experimental mouse models of carcinogenesis expand our understanding of the complex relationship between immune cells and developing tumours. Here, we examine the paradoxical role of adaptive and innate leukocytes as crucial regulators of cancer development and highlight recent insights that have been gained by manipulating immune responses in mouse models of de novo and spontaneous tumorigenesis.",
author = "{De Visser}, {Karin E.} and Alexandra Eichten and Lisa Coussens",
year = "2006",
month = "1",
doi = "10.1038/nrc1782",
language = "English (US)",
volume = "6",
pages = "24--37",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Paradoxical roles of the immune system during cancer development

AU - De Visser, Karin E.

AU - Eichten, Alexandra

AU - Coussens, Lisa

PY - 2006/1

Y1 - 2006/1

N2 - The main function of the mammalian immune system is to monitor tissue homeostasis, to protect against invading or infectious pathogens and to eliminate damaged cells. Therefore, it is surprising that cancer occurs with such a high frequency in humans. Recent insights that have been gained from clinical studies and experimental mouse models of carcinogenesis expand our understanding of the complex relationship between immune cells and developing tumours. Here, we examine the paradoxical role of adaptive and innate leukocytes as crucial regulators of cancer development and highlight recent insights that have been gained by manipulating immune responses in mouse models of de novo and spontaneous tumorigenesis.

AB - The main function of the mammalian immune system is to monitor tissue homeostasis, to protect against invading or infectious pathogens and to eliminate damaged cells. Therefore, it is surprising that cancer occurs with such a high frequency in humans. Recent insights that have been gained from clinical studies and experimental mouse models of carcinogenesis expand our understanding of the complex relationship between immune cells and developing tumours. Here, we examine the paradoxical role of adaptive and innate leukocytes as crucial regulators of cancer development and highlight recent insights that have been gained by manipulating immune responses in mouse models of de novo and spontaneous tumorigenesis.

UR - http://www.scopus.com/inward/record.url?scp=30144443269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30144443269&partnerID=8YFLogxK

U2 - 10.1038/nrc1782

DO - 10.1038/nrc1782

M3 - Article

VL - 6

SP - 24

EP - 37

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

SN - 1474-175X

IS - 1

ER -