TY - JOUR
T1 - Paradoxical aversive conditioning with ethanol
AU - Cunningham, Christopher L.
AU - Linakis, James G.
N1 - Funding Information:
~This research was supported, in part, by a research grant to J. S. Brown from the National Institute on Alcohol Abuse and Alcoholism (AA01229) and by a Biomedical Research Support Grant to the University of Oregon Medical School.
PY - 1980/3
Y1 - 1980/3
N2 - In three experiments with hooded rats, paired injections of ethanol and lithium chloride produced an aversion to the taste of ethanol, yet reduced ethanol's potency as an unconditioned stimulus during subsequent taste aversion conditioning with saccharin (i.e., saccharin→ethanol). Two of the experiments were designed to test an associative "blocking" account of the latter finding. In each of these experiments, an attempt was made to extinguish the aversion conditioned to a potential blocking stimulus after ethanol-lithium pairings, but before saccharain-ethanol conditioning. Nonreinforced exposure to intraperitoneally mediated ethanol taste cues did not eliminate the detrimental effect of ethanol-lithium pairings on subsequent saccharin-ethanol conditioning (Experiment 2), whereas nonreinforced exposure to handling-injection cues did (Experiment 3), thus providing support for the associative blocking interpretation. Implications of these findings for chemical aversion therapy are discussed.
AB - In three experiments with hooded rats, paired injections of ethanol and lithium chloride produced an aversion to the taste of ethanol, yet reduced ethanol's potency as an unconditioned stimulus during subsequent taste aversion conditioning with saccharin (i.e., saccharin→ethanol). Two of the experiments were designed to test an associative "blocking" account of the latter finding. In each of these experiments, an attempt was made to extinguish the aversion conditioned to a potential blocking stimulus after ethanol-lithium pairings, but before saccharain-ethanol conditioning. Nonreinforced exposure to intraperitoneally mediated ethanol taste cues did not eliminate the detrimental effect of ethanol-lithium pairings on subsequent saccharin-ethanol conditioning (Experiment 2), whereas nonreinforced exposure to handling-injection cues did (Experiment 3), thus providing support for the associative blocking interpretation. Implications of these findings for chemical aversion therapy are discussed.
KW - Aversion therapy
KW - Blocking
KW - Ethanol
KW - Lithium chloride
KW - Second-order conditioning
KW - Taste aversion conditioning
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U2 - 10.1016/0091-3057(80)90033-7
DO - 10.1016/0091-3057(80)90033-7
M3 - Article
C2 - 7393933
AN - SCOPUS:0018932288
SN - 0091-3057
VL - 12
SP - 337
EP - 341
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 3
ER -