Paracrine mechanisms of mouse mammary ductal growth

G. R. Cunha, J. F. Wiesen, Z. Werb, P. Young, Y. K. Hom, P. S. Cooke, D. B. Lubahn

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Abstract

Ductal growth during puberty is stimulated by estrogens, which elicit their effects via specific estrogen receptors, ERα and ERβ. Analysis of mice with targeted disruption of ERα or ERβ has emphasized the importance of ERα in mammary gland development. In the mouse mammary gland, ERα are expressed in both epithelial and stromal cells (Kurita and Cunha, unpublished), which raises the possibility that the growth and morphogenetic effects of estrogen could be mediated via either epithelial or stromal ER. The aim of this paper is to review the role of epithelial versus stromal ER in mammary ductalalveolar growth to assess the importance of paracrine mechanisms.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalAdvances in experimental medicine and biology
Volume480
StatePublished - Jan 1 2000

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Cunha, G. R., Wiesen, J. F., Werb, Z., Young, P., Hom, Y. K., Cooke, P. S., & Lubahn, D. B. (2000). Paracrine mechanisms of mouse mammary ductal growth. Advances in experimental medicine and biology, 480, 93-97.