TY - JOUR
T1 - Parabrachial Complex
T2 - A Hub for Pain and Aversion
AU - Chiang, Michael C.
AU - Bowen, Anna
AU - Schier, Lindsey A.
AU - Tupone, Domenico
AU - Uddin, Olivia
AU - Heinricher, Mary M.
PY - 2019/10/16
Y1 - 2019/10/16
N2 - The parabrachial nucleus (PBN) has long been recognized as a sensory relay receiving an array of interoceptive and exteroceptive inputs relevant to taste and ingestive behavior, pain, and multiple aspects of autonomic control, including respiration, blood pressure, water balance, and thermoregulation. Outputs are known to be similarly widespread and complex. How sensory information is handled in PBN and used to inform different outputs to maintain homeostasis and promote survival is only now being elucidated. With a focus on taste and ingestive behaviors, pain, and thermoregulation, this review is intended to provide a context for analysis of PBN circuits involved in aversion and avoidance, and consider how information of various modalities, interoceptive and exteroceptive, is processed within PBN and transmitted to distinct targets to signal challenge, and to engage appropriate behavioral and physiological responses to maintain homeostasis.
AB - The parabrachial nucleus (PBN) has long been recognized as a sensory relay receiving an array of interoceptive and exteroceptive inputs relevant to taste and ingestive behavior, pain, and multiple aspects of autonomic control, including respiration, blood pressure, water balance, and thermoregulation. Outputs are known to be similarly widespread and complex. How sensory information is handled in PBN and used to inform different outputs to maintain homeostasis and promote survival is only now being elucidated. With a focus on taste and ingestive behaviors, pain, and thermoregulation, this review is intended to provide a context for analysis of PBN circuits involved in aversion and avoidance, and consider how information of various modalities, interoceptive and exteroceptive, is processed within PBN and transmitted to distinct targets to signal challenge, and to engage appropriate behavioral and physiological responses to maintain homeostasis.
KW - alarm
KW - brainstem
KW - defense
KW - nociception
KW - taste
KW - thermoregulation
UR - http://www.scopus.com/inward/record.url?scp=85073416222&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073416222&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.1162-19.2019
DO - 10.1523/JNEUROSCI.1162-19.2019
M3 - Article
C2 - 31619491
SN - 0270-6474
VL - 39
SP - 8225
EP - 8230
JO - The Journal of neuroscience : the official journal of the Society for Neuroscience
JF - The Journal of neuroscience : the official journal of the Society for Neuroscience
IS - 42
ER -