TY - JOUR
T1 - Panic Attacks and Phobias
AU - Keefe, Peter H.
AU - Agras, W. Stewart
AU - Marks, Isaac
AU - Neubig, Richard R.
AU - Magarian, Gregory J.
AU - Nardone, David A.
AU - Hedlund, Douglas A.
AU - Sheehan, David V.
PY - 1983/2/10
Y1 - 1983/2/10
N2 - To the Editor: Sheehan (July 15 issue1) cites double-blind, placebo-controlled studies as demonstrating the effectiveness of monoamine oxidase inhibitors and tricyclic antidepressants in treating spontaneous panic attacks.2 3 4 However, in all these studies, imipramine was given in a setting of in vivo exposure, supportive psychotherapy combined with instructions on exposure,2,3 or other, unspecified psychotherapy.4 In patients with agoraphobia who were treated by Zitrin et al.2,3 imipramine seemed to have an early effect on panic but was associated with a higher relapse rale than placebo at six months and one year (30 per cent for imipramine vs. 14 per cent.
AB - To the Editor: Sheehan (July 15 issue1) cites double-blind, placebo-controlled studies as demonstrating the effectiveness of monoamine oxidase inhibitors and tricyclic antidepressants in treating spontaneous panic attacks.2 3 4 However, in all these studies, imipramine was given in a setting of in vivo exposure, supportive psychotherapy combined with instructions on exposure,2,3 or other, unspecified psychotherapy.4 In patients with agoraphobia who were treated by Zitrin et al.2,3 imipramine seemed to have an early effect on panic but was associated with a higher relapse rale than placebo at six months and one year (30 per cent for imipramine vs. 14 per cent.
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U2 - 10.1056/NEJM198302103080615
DO - 10.1056/NEJM198302103080615
M3 - Letter
C2 - 6823236
AN - SCOPUS:85023243547
SN - 0028-4793
VL - 308
SP - 341
EP - 343
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 6
ER -