Panic Attacks and Phobias

Peter H. Keefe, W. Stewart Agras, Isaac Marks, Richard R. Neubig, Gregory Magarian, David A. Nardone, Douglas A. Hedlund, David V. Sheehan

Research output: Contribution to journalLetter

1 Scopus citations


To the Editor: Sheehan (July 15 issue1) cites double-blind, placebo-controlled studies as demonstrating the effectiveness of monoamine oxidase inhibitors and tricyclic antidepressants in treating spontaneous panic attacks.2 3 4 However, in all these studies, imipramine was given in a setting of in vivo exposure, supportive psychotherapy combined with instructions on exposure,2 , 3 or other, unspecified psychotherapy.4 In patients with agoraphobia who were treated by Zitrin et al.2 , 3 imipramine seemed to have an early effect on panic but was associated with a higher relapse rale than placebo at six months and one year (30 per cent for imipramine vs. 14 per cent.

Original languageEnglish (US)
Pages (from-to)341-343
Number of pages3
JournalNew England Journal of Medicine
Issue number6
Publication statusPublished - Feb 10 1983
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Keefe, P. H., Agras, W. S., Marks, I., Neubig, R. R., Magarian, G., Nardone, D. A., ... Sheehan, D. V. (1983). Panic Attacks and Phobias. New England Journal of Medicine, 308(6), 341-343.