Panic Attacks and Phobias

Peter H. Keefe, W. Stewart Agras, Isaac Marks, Richard R. Neubig, Gregory Magarian, David A. Nardone, Douglas A. Hedlund, David V. Sheehan

Research output: Contribution to journalLetter

1 Scopus citations


To the Editor: Sheehan (July 15 issue1) cites double-blind, placebo-controlled studies as demonstrating the effectiveness of monoamine oxidase inhibitors and tricyclic antidepressants in treating spontaneous panic attacks.2 3 4 However, in all these studies, imipramine was given in a setting of in vivo exposure, supportive psychotherapy combined with instructions on exposure,2 , 3 or other, unspecified psychotherapy.4 In patients with agoraphobia who were treated by Zitrin et al.2 , 3 imipramine seemed to have an early effect on panic but was associated with a higher relapse rale than placebo at six months and one year (30 per cent for imipramine vs. 14 per cent.

Original languageEnglish (US)
Pages (from-to)341-343
Number of pages3
JournalNew England Journal of Medicine
Issue number6
StatePublished - Feb 10 1983
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Keefe, P. H., Agras, W. S., Marks, I., Neubig, R. R., Magarian, G., Nardone, D. A., Hedlund, D. A., & Sheehan, D. V. (1983). Panic Attacks and Phobias. New England Journal of Medicine, 308(6), 341-343.