Pancreatitis-diabetes-pancreatic cancer

Summary of an NIDDK-NCI workshop

Dana Andersen, Åke Andren-Sandberg, Eric J. Duell, Michael Goggins, Murray Korc, Gloria M. Petersen, Jill P. Smith, David C. Whitcomb

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

A workshop sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Cancer Institute (NCI) on Pancreatitis-Diabetes-Pancreatic Cancer focused on the risk factors of chronic pancreatitis (CP) and diabetes mellitus (DM) on the development of pancreatic ductal adenocarcinoma (PDAC). Sessions were held on (a) an overview of the problem of PDAC; (b) CP as a risk factor of PDAC; (c) DM as a risk factor of PDAC; (d) pancreatogenic, or type 3c, DM; (e) genomic associations of CP, DM, and PDAC; (f) surveillance of high-risk populations and early detection of PDAC; and (g) effects of DM treatment on PDAC. Recent data and current understandings of the mechanisms of CP- and DM-associated factors on PDAC development were discussed, and a detailed review of the possible risks of DM treatment on the development of PDAC was provided by representatives from academia, industry, and the Food and Drug Administration. The current status of possible biomarkers of PDAC and surveillance strategies for high-risk populations were discussed, and the gaps in knowledge and opportunities for further research were elucidated. A broad spectrum of expertise of the speakers and the discussants provided an unusually productive workshop, the highlights of which are summarized in the accompanying article.

Original languageEnglish (US)
Pages (from-to)1227-1237
Number of pages11
JournalPancreas
Volume42
Issue number8
DOIs
StatePublished - Nov 2013
Externally publishedYes

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National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
National Cancer Institute (U.S.)
Pancreatic Neoplasms
Pancreatitis
Adenocarcinoma
Education
Diabetes Mellitus
Chronic Pancreatitis
United States Food and Drug Administration
Population
Industry

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Andersen, D., Andren-Sandberg, Å., Duell, E. J., Goggins, M., Korc, M., Petersen, G. M., ... Whitcomb, D. C. (2013). Pancreatitis-diabetes-pancreatic cancer: Summary of an NIDDK-NCI workshop. Pancreas, 42(8), 1227-1237. https://doi.org/10.1097/MPA.0b013e3182a9ad9d

Pancreatitis-diabetes-pancreatic cancer : Summary of an NIDDK-NCI workshop. / Andersen, Dana; Andren-Sandberg, Åke; Duell, Eric J.; Goggins, Michael; Korc, Murray; Petersen, Gloria M.; Smith, Jill P.; Whitcomb, David C.

In: Pancreas, Vol. 42, No. 8, 11.2013, p. 1227-1237.

Research output: Contribution to journalArticle

Andersen, D, Andren-Sandberg, Å, Duell, EJ, Goggins, M, Korc, M, Petersen, GM, Smith, JP & Whitcomb, DC 2013, 'Pancreatitis-diabetes-pancreatic cancer: Summary of an NIDDK-NCI workshop', Pancreas, vol. 42, no. 8, pp. 1227-1237. https://doi.org/10.1097/MPA.0b013e3182a9ad9d
Andersen D, Andren-Sandberg Å, Duell EJ, Goggins M, Korc M, Petersen GM et al. Pancreatitis-diabetes-pancreatic cancer: Summary of an NIDDK-NCI workshop. Pancreas. 2013 Nov;42(8):1227-1237. https://doi.org/10.1097/MPA.0b013e3182a9ad9d
Andersen, Dana ; Andren-Sandberg, Åke ; Duell, Eric J. ; Goggins, Michael ; Korc, Murray ; Petersen, Gloria M. ; Smith, Jill P. ; Whitcomb, David C. / Pancreatitis-diabetes-pancreatic cancer : Summary of an NIDDK-NCI workshop. In: Pancreas. 2013 ; Vol. 42, No. 8. pp. 1227-1237.
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