Palmoplantar psoriasis is associated with greater impairment of health-related quality of life compared with moderate to severe plaque psoriasis

Jina Chung, Kristina Callis Duffin, Junko Takeshita, Daniel B. Shin, Gerald G. Krueger, Andrew D. Robertson, Andrea B. Troxel, Abby S. Van Voorhees, Emily Edson-Heredia, Joel M. Gelfand

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Background: The impact of palmoplantar psoriasis on health-related quality of life (QoL) is largely unknown. Objective: We sought to compare clinical characteristics and patient-reported outcomes between patients with palmoplantar psoriasis and moderate to severe plaque psoriasis. Methods: We conducted a cross-sectional study of patients with plaque psoriasis (N = 1153) and palmoplantar psoriasis (N = 66) currently receiving systemic or light treatment for psoriasis. Results: Patients with palmoplantar psoriasisweremore likely to reportDermatology LifeQuality Index scores that correspond to at least a moderate impact on QoL (odds ratio [OR] 2.08; 95% confidence interval [CI] 1.20-3.61); problemswithmobility (OR 1.98; 95% CI 1.10-3.58), self-care (OR 3.12; 95% CI 1.24-7.86), and usual activities (OR 2.47; 95% CI 1.44-4.22) on the European Quality of Life-5 Dimensions questionnaire; and heavy topical prescription use of at least twice daily in the precedingweek (OR 2.81; 95%CI 1.63-4.85) than thosewith plaque psoriasis. Limitations: Our assessment tools may not account for all dimensions of health-related QoL affected by palmoplantar disease, and these results may not be generalizable to patients with milder forms of psoriasis. Conclusion: Patients with palmoplantar psoriasis experience greater health-related QoL impairment and are more likely to report heavy use of topical prescriptions than those with moderate to severe plaque psoriasis.

Original languageEnglish (US)
Pages (from-to)623-632
Number of pages10
JournalJournal of the American Academy of Dermatology
Volume71
Issue number4
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Epidemiology
  • Health-related quality of life
  • Palmoplantar psoriasis
  • Patient-reported outcomes
  • Plaque psoriasis
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology

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