Palisaded neutrophilic and granulomatous dermatosis

Noushin Heidary, Stephanie Mengden, Miriam K. Pomeranz

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A 22-year-old woman with mixed connective-tissue disease presented with a 5-month history of recurrent episodes of tender, erythematous papules, nodules, and edematous plaques on the upper extremities and thighs. Cutaneous lesions occurred in the setting of livedo reticularis. A biopsy specimen showed interstitial and perivascular inflammation with lymphocytes, macrophages, neutrophils, nuclear dust, collagen alteration, extravasated erythrocytes, and fibrin within small superficial blood vessels. These changes were consistent with a diagnosis of palisaded neutrophilic and granulomatous dermatosis, which is a rare entity that includes a combination of a neutrophilic infiltrate, abnormal or altered collagen, granuloma formation, and leukocytoclastic debris in the context of an immune-mediated collagen vascular or systemic disease. The underlying mechanism remains poorly understood. Treatment options are limited, and resolution of lesions typically occurs within several months to years.

Original languageEnglish (US)
Article number17
JournalDermatology Online Journal
Volume14
Issue number5
StatePublished - May 2008
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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