Pairing food and drink: A physiological model of blood ethanol levels for a variety of drinking behaviors

Sharon Moore, Ami Radunskaya, Elizabeth Zollinger, Kathleen A. Grant, Steven Gonzales, Nicole A.R. Walter, Erich J. Baker

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    We present a blood ethanol concentration compartment model which utilizes an animal's ethanol intake, food intake, and weight to predict the animal's blood ethanol concentration at any given time. By incorporating the food digestion process into the model we can predict blood ethanol concentration levels over time for a variety of drinking and eating scenarios. The model is calibrated and validated using data from cohorts of male monkeys, and is able to capture blood ethanol concentration kinetics of the monkeys from a variety of drinking behavior classifications.

    Original languageEnglish (US)
    Article number108778
    JournalMathematical Biosciences
    Volume345
    DOIs
    StatePublished - Mar 2022

    Keywords

    • Alcohol use disorder
    • Differential equations
    • Drinking classification
    • Mathematical modeling

    ASJC Scopus subject areas

    • Statistics and Probability
    • Modeling and Simulation
    • Biochemistry, Genetics and Molecular Biology(all)
    • Immunology and Microbiology(all)
    • Agricultural and Biological Sciences(all)
    • Applied Mathematics

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