TY - JOUR
T1 - Paclitaxel plus carboplatin in advanced non-small-cell lung cancer
T2 - A phase II trial
AU - Johnson, D. H.
AU - Paul, D. M.
AU - Hande, K. R.
AU - Shyr, Y.
AU - Blanke, C.
AU - Murphy, B.
AU - Lewis, M.
AU - De Vore, R. F.
PY - 1996
Y1 - 1996
N2 - Purpose: Studies conducted by the Eastern Cooperative Ontology Group (ECOG) indicate both paclitaxel and carboplatin are associated with an improvement in 1-year survival in patients with stage IV non-small-cell lung cancer (NSCLC). Based on these findings, a phase II trial of these agents in combination was conducted in patients with advanced NSCLC. Patients and Methods: Eligibility included previous untreated stage IIIB or IV NSCLC patients with a good performance status (PS). Paclitaxel (135 or 175 mg/m2) was administered by 24-hour infusion on day 1, followed by a 1-hour infusion of carboplatin on day 2 (300 mg/m2 or dosed to an area under the concentration-time curve [AUC] of 6 mg/mL · min). Treatment was repeated every 28 days for a total of six cycles. Hematopoietic growth factors were not routinely used. Results: Among 51 eligible patients, there were no complete and 14 partial responses, for an overall response rate of 27% (95% confidence interval [CI], 17% to 41%). The median progression-free survival time was 23.8 weeks (range, 12.1 to 73.9) and median survival time, 38 weeks. The survival rate at 1 year was 32%. Grade 3 or 4 granulocytopenia and thrombocytopenia were observed in 47% and 3%, respectively, of the 184 treatment cycles administered. The most common nonhematologic toxicities included nausea and emesis, neuropathy, and arthralgia/myalgia. Conclusion: Paclitaxel plus carboplatin is a moderately active regimen in patients with advanced NSCLC and warrants comparison with existing cisplatin-based regimens in a prospective randomized trial. The toxicities of this regimen are well tolerated in patients with a good PS.
AB - Purpose: Studies conducted by the Eastern Cooperative Ontology Group (ECOG) indicate both paclitaxel and carboplatin are associated with an improvement in 1-year survival in patients with stage IV non-small-cell lung cancer (NSCLC). Based on these findings, a phase II trial of these agents in combination was conducted in patients with advanced NSCLC. Patients and Methods: Eligibility included previous untreated stage IIIB or IV NSCLC patients with a good performance status (PS). Paclitaxel (135 or 175 mg/m2) was administered by 24-hour infusion on day 1, followed by a 1-hour infusion of carboplatin on day 2 (300 mg/m2 or dosed to an area under the concentration-time curve [AUC] of 6 mg/mL · min). Treatment was repeated every 28 days for a total of six cycles. Hematopoietic growth factors were not routinely used. Results: Among 51 eligible patients, there were no complete and 14 partial responses, for an overall response rate of 27% (95% confidence interval [CI], 17% to 41%). The median progression-free survival time was 23.8 weeks (range, 12.1 to 73.9) and median survival time, 38 weeks. The survival rate at 1 year was 32%. Grade 3 or 4 granulocytopenia and thrombocytopenia were observed in 47% and 3%, respectively, of the 184 treatment cycles administered. The most common nonhematologic toxicities included nausea and emesis, neuropathy, and arthralgia/myalgia. Conclusion: Paclitaxel plus carboplatin is a moderately active regimen in patients with advanced NSCLC and warrants comparison with existing cisplatin-based regimens in a prospective randomized trial. The toxicities of this regimen are well tolerated in patients with a good PS.
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U2 - 10.1200/JCO.1996.14.7.2054
DO - 10.1200/JCO.1996.14.7.2054
M3 - Article
C2 - 8683236
AN - SCOPUS:0029901788
SN - 0732-183X
VL - 14
SP - 2054
EP - 2060
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 7
ER -