p85α neomorphic mutants: splitting away from the canonical path

Lydia W.T. Cheung, Gordon Mills

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

PIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy.

Original languageEnglish (US)
Article numbere983388
JournalMolecular and Cellular Oncology
Volume2
Issue number4
DOIs
StatePublished - Oct 2 2015
Externally publishedYes

Keywords

  • MAPK
  • mutation
  • neomorph
  • p85a
  • PI3K
  • PIK3R1

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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