p85α neomorphic mutants: splitting away from the canonical path

Lydia W.T. Cheung; Gordon B. Mills

doi:10.4161/23723556.2014.983388

p85α neomorphic mutants: splitting away from the canonical path

Lydia W.T. Cheung, Gordon B. Mills

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

PIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy.

Original language	English (US)
Article number	e983388
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	4
DOIs	https://doi.org/10.4161/23723556.2014.983388
State	Published - Oct 2 2015
Externally published	Yes

Keywords

MAPK
PI3K
PIK3R1
mutation
neomorph
p85a

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.4161/23723556.2014.983388

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abstract = "PIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy.",

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AB - PIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy.

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p85α neomorphic mutants: splitting away from the canonical path

Abstract

Keywords

ASJC Scopus subject areas

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