Abstract
PIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy.
Original language | English (US) |
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Article number | e983388 |
Journal | Molecular and Cellular Oncology |
Volume | 2 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2 2015 |
Externally published | Yes |
Keywords
- MAPK
- PI3K
- PIK3R1
- mutation
- neomorph
- p85a
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research