P53: Emerging roles in stem cells, development and beyond

Abhinav K. Jain, Michelle Craig Barton

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Most human cancers harbor mutations in the gene encoding p53. As a result, research on p53 in the past few decades has focused primarily on its role as a tumor suppressor. One consequence of this focus is that the functions of p53 in development have largely been ignored. However, recent advances, such as the genomic profiling of embryonic stem cells, have uncovered the significance and mechanisms of p53 functions in mammalian cell differentiation and development. As we review here, these recent findings reveal roles that complement the well-established roles for p53 in tumor suppression.

Original languageEnglish (US)
Article numberdev158360
JournalDevelopment (Cambridge)
Volume145
Issue number8
DOIs
StatePublished - Apr 15 2018
Externally publishedYes

Keywords

  • Development
  • Differentiation
  • Embryonic stem cells
  • LncRNA
  • P53

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

Fingerprint

Dive into the research topics of 'P53: Emerging roles in stem cells, development and beyond'. Together they form a unique fingerprint.

Cite this