p53

Aundrietta D. Duncan, Wen Wei Tsai, Michelle Craig Barton

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

p53 is well known as a major tumor suppressor, primarily due to its multiple functions in cell cycle arrest, senescence or apoptosis, which protect cells against aberrant cell division and propagation of damaged DNA. The gene encoding p53, TP53 in humans, is mutated or dysfunctional in more than 50% of human cancers. More recent studies show that p53 not only acts in tumor suppression but also in differentiation and development, senescence, aging, and metabolism. The addition of metabolic regulation to the compendium of p53 functions in tumor suppression underscores the importance of p53 in cellular homeostasis, along with its roles in maintenance of genome stability and cellular surveillance.

Original languageEnglish (US)
Title of host publicationSignaling Pathways in Liver Diseases
Subtitle of host publicationThird Edition
PublisherWiley-Blackwell
Pages364-373
Number of pages10
ISBN (Electronic)9781118663387
ISBN (Print)9781118663394
DOIs
StatePublished - Sep 28 2015
Externally publishedYes

Keywords

  • Aflatoxin
  • DNA repair
  • Genomic instability
  • MDM2
  • P21
  • PUMA
  • Senescence

ASJC Scopus subject areas

  • Medicine(all)

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