P450 pharmacogenetics in indigenous North American populations

Lindsay M. Henderson, Katrina G. Claw, Erica L. Woodahl, Renee F. Robinson, Bert B. Boyer, Wylie Burke, Kenneth E. Thummel

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Indigenous North American populations, including American Indian and Alaska Native peoples in the United States, the First Nations, Métis and Inuit peoples in Canada and Amerindians in Mexico, are historically under-represented in biomedical research, including genomic research on drug disposition and response. Without adequate representation in pharmacogenetic studies establishing genotype-phenotype relationships, Indigenous populations may not benefit fully from new innovations in precision medicine testing to tailor and improve the safety and efficacy of drug treatment, resulting in health care disparities. The purpose of this review is to summarize and evaluate what is currently known about cytochrome P450 genetic variation in Indigenous populations in North America and to highlight the importance of including these groups in future pharmacogenetic studies for implementation of personalized drug therapy.

Original languageEnglish (US)
Article number9
JournalJournal of Personalized Medicine
Volume8
Issue number1
DOIs
StatePublished - Mar 2018
Externally publishedYes

Keywords

  • Alaska native
  • Allele frequency
  • American Indian
  • Cytochrome P450
  • Drug metabolism
  • First Nations
  • Inuit
  • Mexican Amerindians
  • Pharmacogenetics

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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