P450 Eicosanoids and Reactive Oxygen Species Interplay in Brain Injury and Neuroprotection.

Research output: Contribution to journalArticle

Abstract

SIGNIFICANCE:
Eicosanoids are endogenous lipid mediators that play important roles in brain function and disease. Acute brain injury such as that which occurs in stroke and traumatic brain injury increases the formation of eicosanoids, which, in turn, exacerbate or diminish injury. In chronic neurodegenerative diseases such as Alzheimer's disease and vascular dementia (VD), eicosanoid synthetic and metabolizing enzymes are altered, disrupting the balance between neuroprotective and neurotoxic eicosanoids. Recent Advances: Human and experimental studies have established the opposing roles of hydroxy- and epoxyeicosanoids and their potential utility as diagnostic biomarkers and therapeutic targets in neural injury.
CRITICAL ISSUES:
A gap in knowledge remains in understanding the cellular and molecular mechanisms underlying the neurovascular actions of specific eicosanoids, such as specific isomers of epoxyeicosatrienoic (EETs) and hydroxyeicosatetraenoic acids (HETEs).
FUTURE DIRECTIONS:
EETs and HETEs exert their actions on brain cells by targeting multiple mechanisms, which include surface G-protein coupled receptors. The identification of high-affinity receptors for EETs and HETEs and their cellular localization in the brain will be a breakthrough in our understanding of these eicosanoids as mediators of cell-cell communications and contributors to brain development, function, and disease. Antioxid. Redox Signal. 00, 000-000.
Original languageEnglish (US)
Number of pages21
JournalAntioxidants and Redox Signaling
StatePublished - Apr 20 2017

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Eicosanoids
Brain Injuries
Hydroxyeicosatetraenoic Acids
Reactive Oxygen Species
Brain
Alzheimer Disease
Neurodegenerative diseases
Vascular Dementia
Wounds and Injuries
Brain Diseases
Biomarkers
G-Protein-Coupled Receptors
Cell Communication
Isomers
Neurodegenerative Diseases
Oxidation-Reduction
Neuroprotection
Membrane Proteins
Chronic Disease
Stroke

Keywords

  • : P450 eicosanoids, ROS, brain injury, neuroprotection, epoxyeicosatrienoic (EETs), hydroxyeicosatetraenoic acids (HETEs)

Cite this

@article{238753238f514c4786772b13b3598ecc,
title = "P450 Eicosanoids and Reactive Oxygen Species Interplay in Brain Injury and Neuroprotection.",
abstract = "SIGNIFICANCE:Eicosanoids are endogenous lipid mediators that play important roles in brain function and disease. Acute brain injury such as that which occurs in stroke and traumatic brain injury increases the formation of eicosanoids, which, in turn, exacerbate or diminish injury. In chronic neurodegenerative diseases such as Alzheimer's disease and vascular dementia (VD), eicosanoid synthetic and metabolizing enzymes are altered, disrupting the balance between neuroprotective and neurotoxic eicosanoids. Recent Advances: Human and experimental studies have established the opposing roles of hydroxy- and epoxyeicosanoids and their potential utility as diagnostic biomarkers and therapeutic targets in neural injury.CRITICAL ISSUES:A gap in knowledge remains in understanding the cellular and molecular mechanisms underlying the neurovascular actions of specific eicosanoids, such as specific isomers of epoxyeicosatrienoic (EETs) and hydroxyeicosatetraenoic acids (HETEs).FUTURE DIRECTIONS:EETs and HETEs exert their actions on brain cells by targeting multiple mechanisms, which include surface G-protein coupled receptors. The identification of high-affinity receptors for EETs and HETEs and their cellular localization in the brain will be a breakthrough in our understanding of these eicosanoids as mediators of cell-cell communications and contributors to brain development, function, and disease. Antioxid. Redox Signal. 00, 000-000.",
keywords = ": P450 eicosanoids, ROS, brain injury, neuroprotection, epoxyeicosatrienoic (EETs), hydroxyeicosatetraenoic acids (HETEs)",
author = "Xuehong Liu and Catherine Davis and Nabil Alkayed",
year = "2017",
month = "4",
day = "20",
language = "English (US)",
journal = "Antioxidants and Redox Signaling",
issn = "1523-0864",
publisher = "Mary Ann Liebert Inc.",

}

TY - JOUR

T1 - P450 Eicosanoids and Reactive Oxygen Species Interplay in Brain Injury and Neuroprotection.

AU - Liu, Xuehong

AU - Davis, Catherine

AU - Alkayed, Nabil

PY - 2017/4/20

Y1 - 2017/4/20

N2 - SIGNIFICANCE:Eicosanoids are endogenous lipid mediators that play important roles in brain function and disease. Acute brain injury such as that which occurs in stroke and traumatic brain injury increases the formation of eicosanoids, which, in turn, exacerbate or diminish injury. In chronic neurodegenerative diseases such as Alzheimer's disease and vascular dementia (VD), eicosanoid synthetic and metabolizing enzymes are altered, disrupting the balance between neuroprotective and neurotoxic eicosanoids. Recent Advances: Human and experimental studies have established the opposing roles of hydroxy- and epoxyeicosanoids and their potential utility as diagnostic biomarkers and therapeutic targets in neural injury.CRITICAL ISSUES:A gap in knowledge remains in understanding the cellular and molecular mechanisms underlying the neurovascular actions of specific eicosanoids, such as specific isomers of epoxyeicosatrienoic (EETs) and hydroxyeicosatetraenoic acids (HETEs).FUTURE DIRECTIONS:EETs and HETEs exert their actions on brain cells by targeting multiple mechanisms, which include surface G-protein coupled receptors. The identification of high-affinity receptors for EETs and HETEs and their cellular localization in the brain will be a breakthrough in our understanding of these eicosanoids as mediators of cell-cell communications and contributors to brain development, function, and disease. Antioxid. Redox Signal. 00, 000-000.

AB - SIGNIFICANCE:Eicosanoids are endogenous lipid mediators that play important roles in brain function and disease. Acute brain injury such as that which occurs in stroke and traumatic brain injury increases the formation of eicosanoids, which, in turn, exacerbate or diminish injury. In chronic neurodegenerative diseases such as Alzheimer's disease and vascular dementia (VD), eicosanoid synthetic and metabolizing enzymes are altered, disrupting the balance between neuroprotective and neurotoxic eicosanoids. Recent Advances: Human and experimental studies have established the opposing roles of hydroxy- and epoxyeicosanoids and their potential utility as diagnostic biomarkers and therapeutic targets in neural injury.CRITICAL ISSUES:A gap in knowledge remains in understanding the cellular and molecular mechanisms underlying the neurovascular actions of specific eicosanoids, such as specific isomers of epoxyeicosatrienoic (EETs) and hydroxyeicosatetraenoic acids (HETEs).FUTURE DIRECTIONS:EETs and HETEs exert their actions on brain cells by targeting multiple mechanisms, which include surface G-protein coupled receptors. The identification of high-affinity receptors for EETs and HETEs and their cellular localization in the brain will be a breakthrough in our understanding of these eicosanoids as mediators of cell-cell communications and contributors to brain development, function, and disease. Antioxid. Redox Signal. 00, 000-000.

KW - : P450 eicosanoids, ROS, brain injury, neuroprotection, epoxyeicosatrienoic (EETs), hydroxyeicosatetraenoic acids (HETEs)

M3 - Article

JO - Antioxidants and Redox Signaling

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SN - 1523-0864

ER -