TY - JOUR
T1 - p300 regulates p63 transcriptional activity
AU - MacPartlin, Mary
AU - Zeng, Shelya
AU - Lee, Hunjoo
AU - Stauffer, Daniel
AU - Jin, Yetao
AU - Thayer, Mathew
AU - Lu, Hua
PY - 2005/8/26
Y1 - 2005/8/26
N2 - The transcriptional co-activator p300 has been reported to regulate the tumor suppressor p53 and its ortholog p73. Here we describe a study showing that this coactivator also regulates the transcriptional function of p63. p300 bound to the N-terminal domain of p63γ, and p63γ bound to the N terminus of p300 in vitro and in cells. p300, but not its acetylase-defective mutant AT2, stimulated p63γ-dependent transcription and induction of p21 in cells, consequently leading to G1 arrest. Inversely, the ΔN-p63γ isoform as well as p300AT2 inhibited the induction of p21 by p63γ. These results suggest that p300 regulates p63-dependent transcription of p21.
AB - The transcriptional co-activator p300 has been reported to regulate the tumor suppressor p53 and its ortholog p73. Here we describe a study showing that this coactivator also regulates the transcriptional function of p63. p300 bound to the N-terminal domain of p63γ, and p63γ bound to the N terminus of p300 in vitro and in cells. p300, but not its acetylase-defective mutant AT2, stimulated p63γ-dependent transcription and induction of p21 in cells, consequently leading to G1 arrest. Inversely, the ΔN-p63γ isoform as well as p300AT2 inhibited the induction of p21 by p63γ. These results suggest that p300 regulates p63-dependent transcription of p21.
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U2 - 10.1074/jbc.M503352200
DO - 10.1074/jbc.M503352200
M3 - Article
C2 - 15965232
AN - SCOPUS:24044472029
SN - 0021-9258
VL - 280
SP - 30604
EP - 30610
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 34
ER -