p202 prevents apoptosis in murine AKR-2B fibroblasts

Dimpy Koul, Ruth Lapushin, Hong Ji Xu, Gordon Mills, Jordan U. Gutterman, Divaker Choubey

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

p202 is an interferon (IFN)-inducible, primarily nuclear, phosphoprotein (52-kDa) whose overexpression in transfected cells inhibits colony formation. p202 binds to the retinoblastoma tumor suppressor protein and two other members of the pocket family proteins (p107 and p130). Moreover, overexpression of p202 in transfected cells inhibits the transcriptional activity of E2Fs (E2F-1/DP-1 and E2F-4/DP-1), p53, AP-1 c-Fos and c-Jun, NF-κB p50 and p65. Here we demonstrate that inhibition of endogenous p202 production in murine AKR-2B fibroblasts did not result in an increase in cell proliferation. Instead, these cells exhibited increased susceptibility to apoptosis in response to decrease in serum concentrations in the growth medium. These observations are consistent with the notion that normal levels of p202 may be needed for the regulation of cell proliferation.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume247
Issue number2
DOIs
StatePublished - Jun 18 1998
Externally publishedYes

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Cell proliferation
Fibroblasts
Apoptosis
Tumor Suppressor Proteins
Phosphoproteins
Transcription Factor AP-1
Cell Proliferation
Interferons
Retinoblastoma Protein
Proteins
Growth
Serum
nuclear factor-jun

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

p202 prevents apoptosis in murine AKR-2B fibroblasts. / Koul, Dimpy; Lapushin, Ruth; Xu, Hong Ji; Mills, Gordon; Gutterman, Jordan U.; Choubey, Divaker.

In: Biochemical and Biophysical Research Communications, Vol. 247, No. 2, 18.06.1998, p. 379-382.

Research output: Contribution to journalArticle

Koul, Dimpy ; Lapushin, Ruth ; Xu, Hong Ji ; Mills, Gordon ; Gutterman, Jordan U. ; Choubey, Divaker. / p202 prevents apoptosis in murine AKR-2B fibroblasts. In: Biochemical and Biophysical Research Communications. 1998 ; Vol. 247, No. 2. pp. 379-382.
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