Oxytocin facilitates female sexual maturation through a glia-to-neuron signaling pathway

Anne Simone Parent, Grégory Rasier, Valérie Matagne, Alejandro Lomniczi, Marie Christine Lebrethon, Arlette Gérard, Sergio Ojeda, Jean Pierre Bourguignon

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Abstract

    It has been earlier proposed that oxytocin could play a facilitatory role in the preovulatory LH surge in both rats and humans. We here provide evidence that oxytocin also facilitates sexual maturation in female rats. The administration of an oxytocin antagonist for 6 d to immature female rats decreased GnRH pulse frequency ex vivo and delayed the age at vaginal opening and first estrus. The in vitro reduction in GnRH pulse frequency required chronic blockade of oxytocin receptors, because it was not acutely observed after a single injection of the antagonist. Hypothalamic explants exposed to the antagonist in vitro showed a reduced GnRH pulse frequency and failed to respond to oxytocin with GnRH release. Prostaglandin E2 (PGE2) mimicked the stimulatory effect of oxytocin on GnRH pulse frequency, and inhibition of PG synthesis blocked the effect of oxytocin, suggesting that oxytocin accelerates pulsatile GnRH release via PGE2. The source of PGE2 appears to be astrocytes, because oxytocin stimulates PGE 2 release from cultured hypothalamic astrocytes. Moreover, astrocytes express oxytocin receptors, whereas GnRH neurons do not. These results suggest that oxytocin facilitates female sexual development and that this effect is mediated by a mechanism involving glial production of PGE2.

    Original languageEnglish (US)
    Pages (from-to)1358-1365
    Number of pages8
    JournalEndocrinology
    Volume149
    Issue number3
    DOIs
    StatePublished - Mar 2008

    Fingerprint

    Sexual Maturation
    Oxytocin
    Neuroglia
    Gonadotropin-Releasing Hormone
    Neurons
    Dinoprostone
    Astrocytes
    Oxytocin Receptors
    Sexual Development
    Estrus
    Prostaglandins E
    Injections

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Parent, A. S., Rasier, G., Matagne, V., Lomniczi, A., Lebrethon, M. C., Gérard, A., ... Bourguignon, J. P. (2008). Oxytocin facilitates female sexual maturation through a glia-to-neuron signaling pathway. Endocrinology, 149(3), 1358-1365. https://doi.org/10.1210/en.2007-1054

    Oxytocin facilitates female sexual maturation through a glia-to-neuron signaling pathway. / Parent, Anne Simone; Rasier, Grégory; Matagne, Valérie; Lomniczi, Alejandro; Lebrethon, Marie Christine; Gérard, Arlette; Ojeda, Sergio; Bourguignon, Jean Pierre.

    In: Endocrinology, Vol. 149, No. 3, 03.2008, p. 1358-1365.

    Research output: Contribution to journalArticle

    Parent, AS, Rasier, G, Matagne, V, Lomniczi, A, Lebrethon, MC, Gérard, A, Ojeda, S & Bourguignon, JP 2008, 'Oxytocin facilitates female sexual maturation through a glia-to-neuron signaling pathway', Endocrinology, vol. 149, no. 3, pp. 1358-1365. https://doi.org/10.1210/en.2007-1054
    Parent, Anne Simone ; Rasier, Grégory ; Matagne, Valérie ; Lomniczi, Alejandro ; Lebrethon, Marie Christine ; Gérard, Arlette ; Ojeda, Sergio ; Bourguignon, Jean Pierre. / Oxytocin facilitates female sexual maturation through a glia-to-neuron signaling pathway. In: Endocrinology. 2008 ; Vol. 149, No. 3. pp. 1358-1365.
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