Oxytocin facilitates female sexual maturation through a glia-to-neuron signaling pathway

Anne Simone Parent, Grégory Rasier, Valérie Matagne, Alejandro Lomniczi, Marie Christine Lebrethon, Arlette Gérard, Sergio R. Ojeda, Jean Pierre Bourguignon

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    Abstract

    It has been earlier proposed that oxytocin could play a facilitatory role in the preovulatory LH surge in both rats and humans. We here provide evidence that oxytocin also facilitates sexual maturation in female rats. The administration of an oxytocin antagonist for 6 d to immature female rats decreased GnRH pulse frequency ex vivo and delayed the age at vaginal opening and first estrus. The in vitro reduction in GnRH pulse frequency required chronic blockade of oxytocin receptors, because it was not acutely observed after a single injection of the antagonist. Hypothalamic explants exposed to the antagonist in vitro showed a reduced GnRH pulse frequency and failed to respond to oxytocin with GnRH release. Prostaglandin E2 (PGE2) mimicked the stimulatory effect of oxytocin on GnRH pulse frequency, and inhibition of PG synthesis blocked the effect of oxytocin, suggesting that oxytocin accelerates pulsatile GnRH release via PGE2. The source of PGE2 appears to be astrocytes, because oxytocin stimulates PGE 2 release from cultured hypothalamic astrocytes. Moreover, astrocytes express oxytocin receptors, whereas GnRH neurons do not. These results suggest that oxytocin facilitates female sexual development and that this effect is mediated by a mechanism involving glial production of PGE2.

    Original languageEnglish (US)
    Pages (from-to)1358-1365
    Number of pages8
    JournalEndocrinology
    Volume149
    Issue number3
    DOIs
    StatePublished - Mar 1 2008

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    ASJC Scopus subject areas

    • Endocrinology

    Cite this

    Parent, A. S., Rasier, G., Matagne, V., Lomniczi, A., Lebrethon, M. C., Gérard, A., Ojeda, S. R., & Bourguignon, J. P. (2008). Oxytocin facilitates female sexual maturation through a glia-to-neuron signaling pathway. Endocrinology, 149(3), 1358-1365. https://doi.org/10.1210/en.2007-1054