Abstract
Oxysterols are cholesterol (CH)-oxidized products generated in organs via either enzymatic or non-enzymatic pathways. Their presence or absence in cells, tissues and organs may provide information related to, for example, CH level and environmental status, inflammatory conditions near the CH molecules, activity of specific enzymes at and around the CH site, types and concentrations of biochemicals interacting with the CH, and the existence of specific signals. Here we present a mini-review of our lab findings on oxysterols formation in vitro and in vivo, including: the effects of different reactive species and availability of endogenous compounds on the type of oxysterol generated, the effects of enhanced activity of paraoxonase 1 or hemeoxygenase on oxysterol level, the correlation between human diseases such as diabetes and oxysterol accumulation, and the correlation between oxidative stress in neurons pre-Parkinsonian conditions in an animal model and intracellular oxidative stress.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 438-442 |
| Number of pages | 5 |
| Journal | Chemistry and Physics of Lipids |
| Volume | 164 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 2011 |
| Externally published | Yes |
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Keywords
- Atherosclerosis
- Diabetic
- Oxysterols
- Paraoxonase1
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Cell Biology
Cite this
Oxysterols formation as a reflection of biochemical pathways : Summary of in vitro and in vivo studies. / Vaya, Jacob; Szuchman, Andrea; Tavori, Hagai; Aluf, Yuval.
In: Chemistry and Physics of Lipids, Vol. 164, No. 6, 09.2011, p. 438-442.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oxysterols formation as a reflection of biochemical pathways
T2 - Summary of in vitro and in vivo studies
AU - Vaya, Jacob
AU - Szuchman, Andrea
AU - Tavori, Hagai
AU - Aluf, Yuval
PY - 2011/9
Y1 - 2011/9
N2 - Oxysterols are cholesterol (CH)-oxidized products generated in organs via either enzymatic or non-enzymatic pathways. Their presence or absence in cells, tissues and organs may provide information related to, for example, CH level and environmental status, inflammatory conditions near the CH molecules, activity of specific enzymes at and around the CH site, types and concentrations of biochemicals interacting with the CH, and the existence of specific signals. Here we present a mini-review of our lab findings on oxysterols formation in vitro and in vivo, including: the effects of different reactive species and availability of endogenous compounds on the type of oxysterol generated, the effects of enhanced activity of paraoxonase 1 or hemeoxygenase on oxysterol level, the correlation between human diseases such as diabetes and oxysterol accumulation, and the correlation between oxidative stress in neurons pre-Parkinsonian conditions in an animal model and intracellular oxidative stress.
AB - Oxysterols are cholesterol (CH)-oxidized products generated in organs via either enzymatic or non-enzymatic pathways. Their presence or absence in cells, tissues and organs may provide information related to, for example, CH level and environmental status, inflammatory conditions near the CH molecules, activity of specific enzymes at and around the CH site, types and concentrations of biochemicals interacting with the CH, and the existence of specific signals. Here we present a mini-review of our lab findings on oxysterols formation in vitro and in vivo, including: the effects of different reactive species and availability of endogenous compounds on the type of oxysterol generated, the effects of enhanced activity of paraoxonase 1 or hemeoxygenase on oxysterol level, the correlation between human diseases such as diabetes and oxysterol accumulation, and the correlation between oxidative stress in neurons pre-Parkinsonian conditions in an animal model and intracellular oxidative stress.
KW - Atherosclerosis
KW - Diabetic
KW - Oxysterols
KW - Paraoxonase1
UR - http://www.scopus.com/inward/record.url?scp=80051472916&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051472916&partnerID=8YFLogxK
U2 - 10.1016/j.chemphyslip.2011.03.005
DO - 10.1016/j.chemphyslip.2011.03.005
M3 - Article
C2 - 21514284
AN - SCOPUS:80051472916
VL - 164
SP - 438
EP - 442
JO - Chemistry and Physics of Lipids
JF - Chemistry and Physics of Lipids
SN - 0009-3084
IS - 6
ER -