Oxysterols formation as a reflection of biochemical pathways: Summary of in vitro and in vivo studies

Jacob Vaya, Andrea Szuchman, Hagai Tavori, Yuval Aluf

    Research output: Contribution to journalArticle

    14 Scopus citations

    Abstract

    Oxysterols are cholesterol (CH)-oxidized products generated in organs via either enzymatic or non-enzymatic pathways. Their presence or absence in cells, tissues and organs may provide information related to, for example, CH level and environmental status, inflammatory conditions near the CH molecules, activity of specific enzymes at and around the CH site, types and concentrations of biochemicals interacting with the CH, and the existence of specific signals. Here we present a mini-review of our lab findings on oxysterols formation in vitro and in vivo, including: the effects of different reactive species and availability of endogenous compounds on the type of oxysterol generated, the effects of enhanced activity of paraoxonase 1 or hemeoxygenase on oxysterol level, the correlation between human diseases such as diabetes and oxysterol accumulation, and the correlation between oxidative stress in neurons pre-Parkinsonian conditions in an animal model and intracellular oxidative stress.

    Original languageEnglish (US)
    Pages (from-to)438-442
    Number of pages5
    JournalChemistry and Physics of Lipids
    Volume164
    Issue number6
    DOIs
    StatePublished - Sep 1 2011

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    Keywords

    • Atherosclerosis
    • Diabetic
    • Oxysterols
    • Paraoxonase1

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Organic Chemistry
    • Cell Biology

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