Oxysterols formation as a reflection of biochemical pathways: Summary of in vitro and in vivo studies

Jacob Vaya, Andrea Szuchman, Hagai Tavori, Yuval Aluf

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Oxysterols are cholesterol (CH)-oxidized products generated in organs via either enzymatic or non-enzymatic pathways. Their presence or absence in cells, tissues and organs may provide information related to, for example, CH level and environmental status, inflammatory conditions near the CH molecules, activity of specific enzymes at and around the CH site, types and concentrations of biochemicals interacting with the CH, and the existence of specific signals. Here we present a mini-review of our lab findings on oxysterols formation in vitro and in vivo, including: the effects of different reactive species and availability of endogenous compounds on the type of oxysterol generated, the effects of enhanced activity of paraoxonase 1 or hemeoxygenase on oxysterol level, the correlation between human diseases such as diabetes and oxysterol accumulation, and the correlation between oxidative stress in neurons pre-Parkinsonian conditions in an animal model and intracellular oxidative stress.

Original languageEnglish (US)
Pages (from-to)438-442
Number of pages5
JournalChemistry and Physics of Lipids
Volume164
Issue number6
DOIs
StatePublished - Sep 2011
Externally publishedYes

Fingerprint

Cholesterol
Oxidative stress
Oxidative Stress
Aryldialkylphosphatase
Medical problems
Neurons
Animals
Animal Models
In Vitro Techniques
Oxysterols
Availability
Tissue
Molecules
Enzymes

Keywords

  • Atherosclerosis
  • Diabetic
  • Oxysterols
  • Paraoxonase1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Cell Biology

Cite this

Oxysterols formation as a reflection of biochemical pathways : Summary of in vitro and in vivo studies. / Vaya, Jacob; Szuchman, Andrea; Tavori, Hagai; Aluf, Yuval.

In: Chemistry and Physics of Lipids, Vol. 164, No. 6, 09.2011, p. 438-442.

Research output: Contribution to journalArticle

@article{7517ef7411d449b3a4ad9c6539db0887,
title = "Oxysterols formation as a reflection of biochemical pathways: Summary of in vitro and in vivo studies",
abstract = "Oxysterols are cholesterol (CH)-oxidized products generated in organs via either enzymatic or non-enzymatic pathways. Their presence or absence in cells, tissues and organs may provide information related to, for example, CH level and environmental status, inflammatory conditions near the CH molecules, activity of specific enzymes at and around the CH site, types and concentrations of biochemicals interacting with the CH, and the existence of specific signals. Here we present a mini-review of our lab findings on oxysterols formation in vitro and in vivo, including: the effects of different reactive species and availability of endogenous compounds on the type of oxysterol generated, the effects of enhanced activity of paraoxonase 1 or hemeoxygenase on oxysterol level, the correlation between human diseases such as diabetes and oxysterol accumulation, and the correlation between oxidative stress in neurons pre-Parkinsonian conditions in an animal model and intracellular oxidative stress.",
keywords = "Atherosclerosis, Diabetic, Oxysterols, Paraoxonase1",
author = "Jacob Vaya and Andrea Szuchman and Hagai Tavori and Yuval Aluf",
year = "2011",
month = "9",
doi = "10.1016/j.chemphyslip.2011.03.005",
language = "English (US)",
volume = "164",
pages = "438--442",
journal = "Chemistry and Physics of Lipids",
issn = "0009-3084",
publisher = "Elsevier Ireland Ltd",
number = "6",

}

TY - JOUR

T1 - Oxysterols formation as a reflection of biochemical pathways

T2 - Summary of in vitro and in vivo studies

AU - Vaya, Jacob

AU - Szuchman, Andrea

AU - Tavori, Hagai

AU - Aluf, Yuval

PY - 2011/9

Y1 - 2011/9

N2 - Oxysterols are cholesterol (CH)-oxidized products generated in organs via either enzymatic or non-enzymatic pathways. Their presence or absence in cells, tissues and organs may provide information related to, for example, CH level and environmental status, inflammatory conditions near the CH molecules, activity of specific enzymes at and around the CH site, types and concentrations of biochemicals interacting with the CH, and the existence of specific signals. Here we present a mini-review of our lab findings on oxysterols formation in vitro and in vivo, including: the effects of different reactive species and availability of endogenous compounds on the type of oxysterol generated, the effects of enhanced activity of paraoxonase 1 or hemeoxygenase on oxysterol level, the correlation between human diseases such as diabetes and oxysterol accumulation, and the correlation between oxidative stress in neurons pre-Parkinsonian conditions in an animal model and intracellular oxidative stress.

AB - Oxysterols are cholesterol (CH)-oxidized products generated in organs via either enzymatic or non-enzymatic pathways. Their presence or absence in cells, tissues and organs may provide information related to, for example, CH level and environmental status, inflammatory conditions near the CH molecules, activity of specific enzymes at and around the CH site, types and concentrations of biochemicals interacting with the CH, and the existence of specific signals. Here we present a mini-review of our lab findings on oxysterols formation in vitro and in vivo, including: the effects of different reactive species and availability of endogenous compounds on the type of oxysterol generated, the effects of enhanced activity of paraoxonase 1 or hemeoxygenase on oxysterol level, the correlation between human diseases such as diabetes and oxysterol accumulation, and the correlation between oxidative stress in neurons pre-Parkinsonian conditions in an animal model and intracellular oxidative stress.

KW - Atherosclerosis

KW - Diabetic

KW - Oxysterols

KW - Paraoxonase1

UR - http://www.scopus.com/inward/record.url?scp=80051472916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051472916&partnerID=8YFLogxK

U2 - 10.1016/j.chemphyslip.2011.03.005

DO - 10.1016/j.chemphyslip.2011.03.005

M3 - Article

C2 - 21514284

AN - SCOPUS:80051472916

VL - 164

SP - 438

EP - 442

JO - Chemistry and Physics of Lipids

JF - Chemistry and Physics of Lipids

SN - 0009-3084

IS - 6

ER -