Oxidative stress in patients with endemic pemphigus foliaceus and healthy subjects with anti-desmoglein 1 antibodies

Ericson Leonardo Gutierrez, Lucia Seminario-Vidal, Gerardo Ronceros, Willy Ramos, Mercedes Tello, Alex Ortega Loayza

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Previous studies have shown oxidative stress in pemphigus vulgaris and pemphigus foliaceus, nevertheless, it remains unknown whether a similar response is characteristic of endemic pemphigus foliaceus in Peru. Objectives: To determine the oxidative stress response in endemic pemphigus foliaceus patients and subjects with positive for anti-desmoglein1 antibodies (anti-dsg1) from endemic areas of Peru. Subjects and methods: This is a cross-sectional study. The study population included 21 patients with Endemic Pemphigus foliaceus and 12 healthy subjects with anti-dsg1 antibodies from the Peruvian Amazon (Ucayali), as well as 30 healthy control subjects. Malondialdehyde, an indicator of lipid peroxidation by free radicals, was measured in serum. Results: We collected 21 cases of endemic pemphigus foliaceus, 15 of them with active chronic disease and 6 in clinical remission. Serum malondialdehyde values in patients with chronic active evolution and healthy subjects with anti-dsg1 antibodies were statistically higher than those of healthy controls (p<0.001). There was no significant difference between serum values of localized and generalized clinical forms. Study limitations: The main limitation of this present study is the small number of patients with endemic pemphigus and healthy subjects positive for desmoglein 1 antibodies. Conclusions: The increased serum levels of malondialdehyde in patients with chronic active endemic pemphigus foliaceus and healthy subjects from endemic areas with anti-dsg1 antibodies may suggest a contribution of systemic lipid peroxidation in the pathogenesis of endemic pemphigus foliaceus.

Original languageEnglish (US)
Pages (from-to)212-215
Number of pages4
JournalAnais Brasileiros de Dermatologia
Volume93
Issue number2
DOIs
StatePublished - Mar 1 2018

Fingerprint

Desmoglein 1
Healthy Volunteers
Oxidative Stress
Pemphigus
Antibodies
Anti-Idiotypic Antibodies
Malondialdehyde
Peru
Serum
Lipid Peroxidation
Free Radicals
Pemphigus and fogo selvagem
Chronic Disease
Cross-Sectional Studies

Keywords

  • Malondialdehyde
  • Oxidative stress
  • Pemphigus
  • Peru

ASJC Scopus subject areas

  • Dermatology

Cite this

Oxidative stress in patients with endemic pemphigus foliaceus and healthy subjects with anti-desmoglein 1 antibodies. / Gutierrez, Ericson Leonardo; Seminario-Vidal, Lucia; Ronceros, Gerardo; Ramos, Willy; Tello, Mercedes; Ortega Loayza, Alex.

In: Anais Brasileiros de Dermatologia, Vol. 93, No. 2, 01.03.2018, p. 212-215.

Research output: Contribution to journalArticle

Gutierrez, Ericson Leonardo ; Seminario-Vidal, Lucia ; Ronceros, Gerardo ; Ramos, Willy ; Tello, Mercedes ; Ortega Loayza, Alex. / Oxidative stress in patients with endemic pemphigus foliaceus and healthy subjects with anti-desmoglein 1 antibodies. In: Anais Brasileiros de Dermatologia. 2018 ; Vol. 93, No. 2. pp. 212-215.
@article{c0aa356d584d481c823bab7de0e7c203,
title = "Oxidative stress in patients with endemic pemphigus foliaceus and healthy subjects with anti-desmoglein 1 antibodies",
abstract = "Background: Previous studies have shown oxidative stress in pemphigus vulgaris and pemphigus foliaceus, nevertheless, it remains unknown whether a similar response is characteristic of endemic pemphigus foliaceus in Peru. Objectives: To determine the oxidative stress response in endemic pemphigus foliaceus patients and subjects with positive for anti-desmoglein1 antibodies (anti-dsg1) from endemic areas of Peru. Subjects and methods: This is a cross-sectional study. The study population included 21 patients with Endemic Pemphigus foliaceus and 12 healthy subjects with anti-dsg1 antibodies from the Peruvian Amazon (Ucayali), as well as 30 healthy control subjects. Malondialdehyde, an indicator of lipid peroxidation by free radicals, was measured in serum. Results: We collected 21 cases of endemic pemphigus foliaceus, 15 of them with active chronic disease and 6 in clinical remission. Serum malondialdehyde values in patients with chronic active evolution and healthy subjects with anti-dsg1 antibodies were statistically higher than those of healthy controls (p<0.001). There was no significant difference between serum values of localized and generalized clinical forms. Study limitations: The main limitation of this present study is the small number of patients with endemic pemphigus and healthy subjects positive for desmoglein 1 antibodies. Conclusions: The increased serum levels of malondialdehyde in patients with chronic active endemic pemphigus foliaceus and healthy subjects from endemic areas with anti-dsg1 antibodies may suggest a contribution of systemic lipid peroxidation in the pathogenesis of endemic pemphigus foliaceus.",
keywords = "Malondialdehyde, Oxidative stress, Pemphigus, Peru",
author = "Gutierrez, {Ericson Leonardo} and Lucia Seminario-Vidal and Gerardo Ronceros and Willy Ramos and Mercedes Tello and {Ortega Loayza}, Alex",
year = "2018",
month = "3",
day = "1",
doi = "10.1590/abd1806-4841.20186211",
language = "English (US)",
volume = "93",
pages = "212--215",
journal = "Anais Brasileiros de Dermatologia",
issn = "0365-0596",
publisher = "Sociedade Brasileira de Dermatologia",
number = "2",

}

TY - JOUR

T1 - Oxidative stress in patients with endemic pemphigus foliaceus and healthy subjects with anti-desmoglein 1 antibodies

AU - Gutierrez, Ericson Leonardo

AU - Seminario-Vidal, Lucia

AU - Ronceros, Gerardo

AU - Ramos, Willy

AU - Tello, Mercedes

AU - Ortega Loayza, Alex

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background: Previous studies have shown oxidative stress in pemphigus vulgaris and pemphigus foliaceus, nevertheless, it remains unknown whether a similar response is characteristic of endemic pemphigus foliaceus in Peru. Objectives: To determine the oxidative stress response in endemic pemphigus foliaceus patients and subjects with positive for anti-desmoglein1 antibodies (anti-dsg1) from endemic areas of Peru. Subjects and methods: This is a cross-sectional study. The study population included 21 patients with Endemic Pemphigus foliaceus and 12 healthy subjects with anti-dsg1 antibodies from the Peruvian Amazon (Ucayali), as well as 30 healthy control subjects. Malondialdehyde, an indicator of lipid peroxidation by free radicals, was measured in serum. Results: We collected 21 cases of endemic pemphigus foliaceus, 15 of them with active chronic disease and 6 in clinical remission. Serum malondialdehyde values in patients with chronic active evolution and healthy subjects with anti-dsg1 antibodies were statistically higher than those of healthy controls (p<0.001). There was no significant difference between serum values of localized and generalized clinical forms. Study limitations: The main limitation of this present study is the small number of patients with endemic pemphigus and healthy subjects positive for desmoglein 1 antibodies. Conclusions: The increased serum levels of malondialdehyde in patients with chronic active endemic pemphigus foliaceus and healthy subjects from endemic areas with anti-dsg1 antibodies may suggest a contribution of systemic lipid peroxidation in the pathogenesis of endemic pemphigus foliaceus.

AB - Background: Previous studies have shown oxidative stress in pemphigus vulgaris and pemphigus foliaceus, nevertheless, it remains unknown whether a similar response is characteristic of endemic pemphigus foliaceus in Peru. Objectives: To determine the oxidative stress response in endemic pemphigus foliaceus patients and subjects with positive for anti-desmoglein1 antibodies (anti-dsg1) from endemic areas of Peru. Subjects and methods: This is a cross-sectional study. The study population included 21 patients with Endemic Pemphigus foliaceus and 12 healthy subjects with anti-dsg1 antibodies from the Peruvian Amazon (Ucayali), as well as 30 healthy control subjects. Malondialdehyde, an indicator of lipid peroxidation by free radicals, was measured in serum. Results: We collected 21 cases of endemic pemphigus foliaceus, 15 of them with active chronic disease and 6 in clinical remission. Serum malondialdehyde values in patients with chronic active evolution and healthy subjects with anti-dsg1 antibodies were statistically higher than those of healthy controls (p<0.001). There was no significant difference between serum values of localized and generalized clinical forms. Study limitations: The main limitation of this present study is the small number of patients with endemic pemphigus and healthy subjects positive for desmoglein 1 antibodies. Conclusions: The increased serum levels of malondialdehyde in patients with chronic active endemic pemphigus foliaceus and healthy subjects from endemic areas with anti-dsg1 antibodies may suggest a contribution of systemic lipid peroxidation in the pathogenesis of endemic pemphigus foliaceus.

KW - Malondialdehyde

KW - Oxidative stress

KW - Pemphigus

KW - Peru

UR - http://www.scopus.com/inward/record.url?scp=85046416523&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046416523&partnerID=8YFLogxK

U2 - 10.1590/abd1806-4841.20186211

DO - 10.1590/abd1806-4841.20186211

M3 - Article

C2 - 29723379

AN - SCOPUS:85046416523

VL - 93

SP - 212

EP - 215

JO - Anais Brasileiros de Dermatologia

JF - Anais Brasileiros de Dermatologia

SN - 0365-0596

IS - 2

ER -