Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles

Jingga Morry, Worapol Ngamcherdtrakul, Wassana Yantasee

Research output: Contribution to journalReview article

90 Scopus citations

Abstract

Oxidative stress, mainly contributed by reactive oxygen species (ROS), has been implicated in pathogenesis of several diseases. We review two primary examples; fibrosis and cancer. In fibrosis, ROS promote activation and proliferation of fibroblasts and myofibroblasts, activating TGF-β pathway in an autocrine manner. In cancer, ROS account for its genomic instability, resistance to apoptosis, proliferation, and angiogenesis. Importantly, ROS trigger cancer cell invasion through invadopodia formation as well as extravasation into a distant metastasis site. Use of antioxidant supplements, enzymes, and inhibitors for ROS-generating NADPH oxidases (NOX) is a logical therapeutic intervention for fibrosis and cancer. We review such attempts, progress, and challenges. Lastly, we review how nanoparticles with inherent antioxidant activity can also be a promising therapeutic option, considering their additional feature as a delivery platform for drugs, genes, and imaging agents.

Original languageEnglish (US)
Pages (from-to)240-253
Number of pages14
JournalRedox Biology
Volume11
DOIs
StatePublished - Apr 1 2017

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Keywords

  • Antioxidant
  • Cancer
  • Fibrosis
  • Metastasis
  • Nanoparticles
  • ROS

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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