Oxidative damage and age-related functional declines

Ian Martin, Michael S. Grotewiel

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Most organisms experience progressive declines in physiological function as they age. Since this senescence of function is thought to underlie the decrease in quality of life in addition to the increase in susceptibility to disease and death associated with aging, identifying the mechanisms involved would be highly beneficial. One of the leading mechanistic theories for aging is the oxidative damage hypothesis. A number of studies in a variety of species support a strong link between oxidative damage and life span determination. The role of oxidative damage in functional senescence has also been investigated, albeit not as comprehensively. Here, we review these investigations. Several studies show that the age-related loss of a number of functions is associated with an accrual of oxidative damage in the tissues mediating those functions. Additionally, treatments that increase the accumulation of oxidative damage with age frequently exacerbate functional losses. Moreover, treatments that reduce the accumulation of oxidative damage often attenuate or delay the loss of function associated with aging. These data provide the foundation for a link between oxidative damage and functional senescence, thereby supporting the oxidative damage hypothesis of aging within the context of age-related functional decline.

Original languageEnglish (US)
Pages (from-to)411-423
Number of pages13
JournalMechanisms of Ageing and Development
Volume127
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

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Aging of materials
Disease Susceptibility
Quality of Life
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Keywords

  • Aging
  • Antioxidants
  • Oxidative damage
  • Senescence

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Oxidative damage and age-related functional declines. / Martin, Ian; Grotewiel, Michael S.

In: Mechanisms of Ageing and Development, Vol. 127, No. 5, 05.2006, p. 411-423.

Research output: Contribution to journalArticle

Martin, Ian ; Grotewiel, Michael S. / Oxidative damage and age-related functional declines. In: Mechanisms of Ageing and Development. 2006 ; Vol. 127, No. 5. pp. 411-423.
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