Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions

Andy I. Chen, Alexander J. McAdam, Janet E. Buhlmann, Sumi Scott, Mark L. Lupher, Edward A. Greenfield, Peter R. Baum, William C. Fanslow, David M. Calderhead, Gordon J. Freeman, Arlene H. Sharpe

Research output: Contribution to journalArticle

260 Scopus citations

Abstract

The tumor necrosis factor family molecule Ox40-ligand (Ox40L) has been identified as a potential costimulatory molecule and also has been implicated in T cell homing and B cell activation. To ascertain the essential functions of Ox40L, we generated and characterized Ox40L-deficient mice. Mice lacking Ox40L exhibit an impaired contact hypersensitivity response, a dendritic cell-dependent T cell-mediated response, due to defects in T cell priming and cytokine production. In contrast, Ox40L-deficient mice do not have defects in T cell homing or humoral immune responses. In vitro, Ox40L-deficient dendritic cells are defective in costimulating T cell cytokine production. Thus, Ox40L has a critical costimulatory function in vitro and in vivo for dendritic cell:T cell interactions.

Original languageEnglish (US)
Pages (from-to)689-698
Number of pages10
JournalImmunity
Volume11
Issue number6
DOIs
StatePublished - Dec 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Chen, A. I., McAdam, A. J., Buhlmann, J. E., Scott, S., Lupher, M. L., Greenfield, E. A., Baum, P. R., Fanslow, W. C., Calderhead, D. M., Freeman, G. J., & Sharpe, A. H. (1999). Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Immunity, 11(6), 689-698. https://doi.org/10.1016/S1074-7613(00)80143-0