Ovine corticotropin-releasing factor administration in normal men: Pituitary and adrenal responses in the morning and evening

Heinrich M. Schulte, George P. Chrousos, Edward H. Oldfield, Philip W. Gold, Gordon B. Culler, Donald (Lynn) Loriaux

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

We administered ovine corticotropin-releasing factor (CRF) as a bolus intravenous injection (1 μg/kg) at 09.00 and at 20.00 to assess the influence of circadian changes in the hypothalamic-pituitary-adrenal axis on the response to CRF. The increase in plasma ACTH levels after CRF was only slightly lower in the morning than in the evening. The plasma Cortisol response to ACTH, however, was significantly greater in the evening than in the morning (p <0.005). At both times of day CRF administration had no effect on plasma concentrations of GH, PRL, LH, AVP, insulin. PRA or glucose. No effects were observed on the hematopoietic system, kidneys or liver. In addition. CRF had no effect on heart rate, blood pressure or respiratory rate at the dose employed. Approximately 10% of the subjects complained of a transient upper body and facial hoi flush. These observations indicate that the magnitude of the plasma Cortisol rise after CRF depends on the time of administration.

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalHormone Research in Paediatrics
Volume21
Issue number2
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Sheep
Adrenocorticotropic Hormone
Hydrocortisone
Hematopoietic System
Respiratory Rate
Intravenous Injections
Heart Rate
Insulin
Blood Pressure
Kidney
Glucose
Liver

Keywords

  • CRF responses in the morning and evening
  • Ovine corticotropin-releasing factor

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Ovine corticotropin-releasing factor administration in normal men : Pituitary and adrenal responses in the morning and evening. / Schulte, Heinrich M.; Chrousos, George P.; Oldfield, Edward H.; Gold, Philip W.; Culler, Gordon B.; Loriaux, Donald (Lynn).

In: Hormone Research in Paediatrics, Vol. 21, No. 2, 1985, p. 69-74.

Research output: Contribution to journalArticle

Schulte, Heinrich M. ; Chrousos, George P. ; Oldfield, Edward H. ; Gold, Philip W. ; Culler, Gordon B. ; Loriaux, Donald (Lynn). / Ovine corticotropin-releasing factor administration in normal men : Pituitary and adrenal responses in the morning and evening. In: Hormone Research in Paediatrics. 1985 ; Vol. 21, No. 2. pp. 69-74.
@article{155c235c1b544d54842312c843f35309,
title = "Ovine corticotropin-releasing factor administration in normal men: Pituitary and adrenal responses in the morning and evening",
abstract = "We administered ovine corticotropin-releasing factor (CRF) as a bolus intravenous injection (1 μg/kg) at 09.00 and at 20.00 to assess the influence of circadian changes in the hypothalamic-pituitary-adrenal axis on the response to CRF. The increase in plasma ACTH levels after CRF was only slightly lower in the morning than in the evening. The plasma Cortisol response to ACTH, however, was significantly greater in the evening than in the morning (p <0.005). At both times of day CRF administration had no effect on plasma concentrations of GH, PRL, LH, AVP, insulin. PRA or glucose. No effects were observed on the hematopoietic system, kidneys or liver. In addition. CRF had no effect on heart rate, blood pressure or respiratory rate at the dose employed. Approximately 10{\%} of the subjects complained of a transient upper body and facial hoi flush. These observations indicate that the magnitude of the plasma Cortisol rise after CRF depends on the time of administration.",
keywords = "CRF responses in the morning and evening, Ovine corticotropin-releasing factor",
author = "Schulte, {Heinrich M.} and Chrousos, {George P.} and Oldfield, {Edward H.} and Gold, {Philip W.} and Culler, {Gordon B.} and Loriaux, {Donald (Lynn)}",
year = "1985",
doi = "10.1159/000180028",
language = "English (US)",
volume = "21",
pages = "69--74",
journal = "Hormone Research in Paediatrics",
issn = "1663-2818",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Ovine corticotropin-releasing factor administration in normal men

T2 - Pituitary and adrenal responses in the morning and evening

AU - Schulte, Heinrich M.

AU - Chrousos, George P.

AU - Oldfield, Edward H.

AU - Gold, Philip W.

AU - Culler, Gordon B.

AU - Loriaux, Donald (Lynn)

PY - 1985

Y1 - 1985

N2 - We administered ovine corticotropin-releasing factor (CRF) as a bolus intravenous injection (1 μg/kg) at 09.00 and at 20.00 to assess the influence of circadian changes in the hypothalamic-pituitary-adrenal axis on the response to CRF. The increase in plasma ACTH levels after CRF was only slightly lower in the morning than in the evening. The plasma Cortisol response to ACTH, however, was significantly greater in the evening than in the morning (p <0.005). At both times of day CRF administration had no effect on plasma concentrations of GH, PRL, LH, AVP, insulin. PRA or glucose. No effects were observed on the hematopoietic system, kidneys or liver. In addition. CRF had no effect on heart rate, blood pressure or respiratory rate at the dose employed. Approximately 10% of the subjects complained of a transient upper body and facial hoi flush. These observations indicate that the magnitude of the plasma Cortisol rise after CRF depends on the time of administration.

AB - We administered ovine corticotropin-releasing factor (CRF) as a bolus intravenous injection (1 μg/kg) at 09.00 and at 20.00 to assess the influence of circadian changes in the hypothalamic-pituitary-adrenal axis on the response to CRF. The increase in plasma ACTH levels after CRF was only slightly lower in the morning than in the evening. The plasma Cortisol response to ACTH, however, was significantly greater in the evening than in the morning (p <0.005). At both times of day CRF administration had no effect on plasma concentrations of GH, PRL, LH, AVP, insulin. PRA or glucose. No effects were observed on the hematopoietic system, kidneys or liver. In addition. CRF had no effect on heart rate, blood pressure or respiratory rate at the dose employed. Approximately 10% of the subjects complained of a transient upper body and facial hoi flush. These observations indicate that the magnitude of the plasma Cortisol rise after CRF depends on the time of administration.

KW - CRF responses in the morning and evening

KW - Ovine corticotropin-releasing factor

UR - http://www.scopus.com/inward/record.url?scp=0021972631&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021972631&partnerID=8YFLogxK

U2 - 10.1159/000180028

DO - 10.1159/000180028

M3 - Article

C2 - 2984099

AN - SCOPUS:0021972631

VL - 21

SP - 69

EP - 74

JO - Hormone Research in Paediatrics

JF - Hormone Research in Paediatrics

SN - 1663-2818

IS - 2

ER -