Overview of mouse assays of ethanol intoxication

John C. Crabbe, Andy J. Cameron, Elizabeth Munn, Mark Bunning, Douglas Wahlsten

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

There are many behavioral assays to assess sensitivity to ethanol intoxication in mice. Most are simple to implement, and are sensitive to a particular dose range of ethanol. Most reflect genetic influences, and each test appears to reflect the contribution of a relatively distinct collection of genes. This genetic heterogeneity implies that no single test can claim to capture the construct "ethanol intoxication" completely. Depending on the test, and when measurements are made, acute functional tolerance to even a single dose of ethanol must be considered as a contributing factor. Whether or not a test is conducted in naïvemice or as part of a test battery can influence sensitivity, and do so in a strain-dependent manner. This unit reviews existing tests and recommends several.

Original languageEnglish (US)
Pages (from-to)9.26.1-9.26.19
JournalCurrent Protocols in Neuroscience
Issue numberSUPPL. 42
DOIs
StatePublished - 2008

Keywords

  • Ataxia
  • Ethanol
  • Genetics
  • Inbred strains
  • Intoxication
  • Mouse
  • Test batteries

ASJC Scopus subject areas

  • Neuroscience(all)

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    Crabbe, J. C., Cameron, A. J., Munn, E., Bunning, M., & Wahlsten, D. (2008). Overview of mouse assays of ethanol intoxication. Current Protocols in Neuroscience, (SUPPL. 42), 9.26.1-9.26.19. https://doi.org/10.1002/0471142301.ns0926s42