Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy

M. C. Gong, S. S. Chang, F. Watt, D. S. O'Keefe, D. J. Bacich, A. Uchida, N. H. Bander, V. E. Reuter, P. B. Gaudin, P. L. Molloy, M. Sadelian, W. D.W. Heston, S. Howell, W. Sakr, D. Bostwick, N. Bruchovsky, M. Garnick, N. Stone, M. Garzotto

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Prostate-specific membrane antigen (PSMA) is a potential target in prostate cancer patients because it is very highly expressed and because it has been reported to be upregulated by androgen deprivation. This overview addresses the expression of the PSMA gene in terms of the promoter and enhancer and how that may play a role in gene therapy. We also review PSMA as a target for antibodies for imaging and treatment and the development of a novel hybrid T-cell receptor that combines the specificity of anti-PSMA antibodies with that of T-cell receptor activation when introduced into primary lymphocytes by retroviral-mediated gene transfer. We also discuss our recent findings on the expression of a PSMA-like gene and how that understanding allows specific targeting of PSMA.

Original languageEnglish (US)
Pages (from-to)217-223
Number of pages7
JournalMolecular Urology
Volume4
Issue number3
StatePublished - Nov 13 2000

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy'. Together they form a unique fingerprint.

  • Cite this

    Gong, M. C., Chang, S. S., Watt, F., O'Keefe, D. S., Bacich, D. J., Uchida, A., Bander, N. H., Reuter, V. E., Gaudin, P. B., Molloy, P. L., Sadelian, M., Heston, W. D. W., Howell, S., Sakr, W., Bostwick, D., Bruchovsky, N., Garnick, M., Stone, N., & Garzotto, M. (2000). Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy. Molecular Urology, 4(3), 217-223.