Lipid peroxidation has been associated with many pathological conditions, especially age-related diseases. While this association is becoming tighter and the body of evidence strongly supporting a role for lipid peroxidation in the pathogenesis of atherosclerosis, cancer, and neurodegeneration, significant questions remain. What are the major sources of free radicals in each of these diseases? Answers to this question will have important therapeutic implications. What are the mechanisms by which lipid peroxidation contributes to the initiation or progression of disease? Answers to this question will deepen our understanding of the pathogenesis of age-related diseases.
ASJC Scopus subject areas
- Geriatrics and Gerontology