TY - JOUR
T1 - Overview
T2 - Membrane lipid peroxidation
AU - Montine, Kathleen S.
AU - Quinn, Joseph F.
AU - Montine, Thomas J.
PY - 2003
Y1 - 2003
N2 - Lipid peroxidation has been associated with many pathological conditions, especially age-related diseases. While this association is becoming tighter and the body of evidence strongly supporting a role for lipid peroxidation in the pathogenesis of atherosclerosis, cancer, and neurodegeneration, significant questions remain. What are the major sources of free radicals in each of these diseases? Answers to this question will have important therapeutic implications. What are the mechanisms by which lipid peroxidation contributes to the initiation or progression of disease? Answers to this question will deepen our understanding of the pathogenesis of age-related diseases.
AB - Lipid peroxidation has been associated with many pathological conditions, especially age-related diseases. While this association is becoming tighter and the body of evidence strongly supporting a role for lipid peroxidation in the pathogenesis of atherosclerosis, cancer, and neurodegeneration, significant questions remain. What are the major sources of free radicals in each of these diseases? Answers to this question will have important therapeutic implications. What are the mechanisms by which lipid peroxidation contributes to the initiation or progression of disease? Answers to this question will deepen our understanding of the pathogenesis of age-related diseases.
UR - http://www.scopus.com/inward/record.url?scp=36148943517&partnerID=8YFLogxK
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U2 - 10.1016/S1566-3124(03)12002-0
DO - 10.1016/S1566-3124(03)12002-0
M3 - Review article
AN - SCOPUS:36148943517
SN - 1566-3124
VL - 12
SP - 11
EP - 26
JO - Advances in Cell Aging and Gerontology
JF - Advances in Cell Aging and Gerontology
ER -