Overproduction of corticotropin-releasing hormone blocks germinal center formation: Role of corticosterone and impaired follicular dendritic cell networks

Susan Murray, Holly Rosenzweig, Martha Johnson, Mark O. Huising, Kristine Sawicki, Mary Stenzel-Poore

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Corticotropin-releasing hormone (CRH) is a central mediator in the response to stress, coordinating behavioral, autonomic and neuroendocrine activation. CRH overproduction is implicated in several affective disorders, including major depression, panic-anxiety disorder and anorexia-diseases also associated with altered immune function. We investigated the link between CRH overdrive and immune function using CRH transgenic mice. Following immunization, CRH transgenic mice fail to form germinal centers; chronic glucocorticoid administration recapitulates this effect in wild-type mice. Regulation of germinal centers by glucocorticoids appears to be mediated, in part, through effects on follicular dendritic cells (FDC), providing a novel mechanism by which CRH dysregulation may significantly impair humoral immune responses.

Original languageEnglish (US)
Pages (from-to)31-41
Number of pages11
JournalJournal of Neuroimmunology
Volume156
Issue number1-2
DOIs
Publication statusPublished - Nov 2004

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Keywords

  • Antibodies
  • B lymphocytes
  • Follicular dendritic cell
  • Germinal center
  • Immunization
  • Transgenic

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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