Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability

Meejeon Roh, Bernard Gary, Chisu Song, Nasser Said-Al-Naief, Albert Tousson, Andrew Kraft, Isam Eldin Eltoum, Sarki A. Abdulkadir

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.

Original languageEnglish (US)
Pages (from-to)8079-8084
Number of pages6
JournalCancer Research
Volume63
Issue number23
StatePublished - Dec 1 2003
Externally publishedYes

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Proto-Oncogene Proteins c-pim-1
Genomic Instability
M Phase Cell Cycle Checkpoints
Aneuploidy
Prostate
Centrosome
Spindle Apparatus
Polyploidy
Cytokinesis
Chromosome Aberrations
Neoplasms
Chromosomes
Epithelial Cells

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Roh, M., Gary, B., Song, C., Said-Al-Naief, N., Tousson, A., Kraft, A., ... Abdulkadir, S. A. (2003). Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability. Cancer Research, 63(23), 8079-8084.

Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability. / Roh, Meejeon; Gary, Bernard; Song, Chisu; Said-Al-Naief, Nasser; Tousson, Albert; Kraft, Andrew; Eltoum, Isam Eldin; Abdulkadir, Sarki A.

In: Cancer Research, Vol. 63, No. 23, 01.12.2003, p. 8079-8084.

Research output: Contribution to journalArticle

Roh, M, Gary, B, Song, C, Said-Al-Naief, N, Tousson, A, Kraft, A, Eltoum, IE & Abdulkadir, SA 2003, 'Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability', Cancer Research, vol. 63, no. 23, pp. 8079-8084.
Roh M, Gary B, Song C, Said-Al-Naief N, Tousson A, Kraft A et al. Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability. Cancer Research. 2003 Dec 1;63(23):8079-8084.
Roh, Meejeon ; Gary, Bernard ; Song, Chisu ; Said-Al-Naief, Nasser ; Tousson, Albert ; Kraft, Andrew ; Eltoum, Isam Eldin ; Abdulkadir, Sarki A. / Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability. In: Cancer Research. 2003 ; Vol. 63, No. 23. pp. 8079-8084.
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