Ovarian tissue transport to expand access to fertility preservation: From animals to clinical practice

Francesca E. Duncan, Mary Zelinski, Alexander H. Gunn, Jennifer E. Pahnke, Conor L. O'Neill, Nucharin Songsasen, Ryan I. Woodruff, Teresa K. Woodruff

    Research output: Contribution to journalReview article

    14 Citations (Scopus)

    Abstract

    Primordial follicles dictate a female's reproductive life span and therefore are central to fertility preservation for both endangered species and individuals with fertility-threatening conditions. Ovarian tissue containing primordial follicles can be cryopreserved and later thawed and transplanted back into individuals to restore both endocrine function and fertility. Importantly, increasing numbers of human live births have been reported following ovarian tissue cryopreservation and transplantation. A current limitation of this technology is patient access to sites that are approved or equipped to process and cryopreserve ovarian tissue - especially in larger countries or low resource settings. Here, we review empirical evidence from both animal models and human studies that suggest that ovarian tissue can be transported at cold temperatures for several hours while still maintaining the integrity and reproductive potential of the primordial follicles within the tissue. In fact, several human live births have been reported in European countries using tissue that was transported at cold temperatures for up to 20 h before cryopreservation and transplantation. Ovarian tissue transport, if implemented widely in clinical practice, could therefore expand both patient and provider access to emerging fertility preservation options.

    Original languageEnglish (US)
    Pages (from-to)R201-R210
    JournalReproduction
    Volume152
    Issue number6
    DOIs
    StatePublished - 2016

    Fingerprint

    Fertility Preservation
    Cryopreservation
    Live Birth
    Fertility
    Tissue Transplantation
    Endangered Species
    Animal Models
    Transplantation
    Technology

    ASJC Scopus subject areas

    • Embryology
    • Reproductive Medicine
    • Endocrinology
    • Obstetrics and Gynecology
    • Cell Biology

    Cite this

    Duncan, F. E., Zelinski, M., Gunn, A. H., Pahnke, J. E., O'Neill, C. L., Songsasen, N., ... Woodruff, T. K. (2016). Ovarian tissue transport to expand access to fertility preservation: From animals to clinical practice. Reproduction, 152(6), R201-R210. https://doi.org/10.1530/REP-15-0598

    Ovarian tissue transport to expand access to fertility preservation : From animals to clinical practice. / Duncan, Francesca E.; Zelinski, Mary; Gunn, Alexander H.; Pahnke, Jennifer E.; O'Neill, Conor L.; Songsasen, Nucharin; Woodruff, Ryan I.; Woodruff, Teresa K.

    In: Reproduction, Vol. 152, No. 6, 2016, p. R201-R210.

    Research output: Contribution to journalReview article

    Duncan, FE, Zelinski, M, Gunn, AH, Pahnke, JE, O'Neill, CL, Songsasen, N, Woodruff, RI & Woodruff, TK 2016, 'Ovarian tissue transport to expand access to fertility preservation: From animals to clinical practice', Reproduction, vol. 152, no. 6, pp. R201-R210. https://doi.org/10.1530/REP-15-0598
    Duncan, Francesca E. ; Zelinski, Mary ; Gunn, Alexander H. ; Pahnke, Jennifer E. ; O'Neill, Conor L. ; Songsasen, Nucharin ; Woodruff, Ryan I. ; Woodruff, Teresa K. / Ovarian tissue transport to expand access to fertility preservation : From animals to clinical practice. In: Reproduction. 2016 ; Vol. 152, No. 6. pp. R201-R210.
    @article{fc1141a3d39e4b1484ca9981409134a0,
    title = "Ovarian tissue transport to expand access to fertility preservation: From animals to clinical practice",
    abstract = "Primordial follicles dictate a female's reproductive life span and therefore are central to fertility preservation for both endangered species and individuals with fertility-threatening conditions. Ovarian tissue containing primordial follicles can be cryopreserved and later thawed and transplanted back into individuals to restore both endocrine function and fertility. Importantly, increasing numbers of human live births have been reported following ovarian tissue cryopreservation and transplantation. A current limitation of this technology is patient access to sites that are approved or equipped to process and cryopreserve ovarian tissue - especially in larger countries or low resource settings. Here, we review empirical evidence from both animal models and human studies that suggest that ovarian tissue can be transported at cold temperatures for several hours while still maintaining the integrity and reproductive potential of the primordial follicles within the tissue. In fact, several human live births have been reported in European countries using tissue that was transported at cold temperatures for up to 20 h before cryopreservation and transplantation. Ovarian tissue transport, if implemented widely in clinical practice, could therefore expand both patient and provider access to emerging fertility preservation options.",
    author = "Duncan, {Francesca E.} and Mary Zelinski and Gunn, {Alexander H.} and Pahnke, {Jennifer E.} and O'Neill, {Conor L.} and Nucharin Songsasen and Woodruff, {Ryan I.} and Woodruff, {Teresa K.}",
    year = "2016",
    doi = "10.1530/REP-15-0598",
    language = "English (US)",
    volume = "152",
    pages = "R201--R210",
    journal = "Reproduction",
    issn = "1470-1626",
    publisher = "BioScientifica Ltd.",
    number = "6",

    }

    TY - JOUR

    T1 - Ovarian tissue transport to expand access to fertility preservation

    T2 - From animals to clinical practice

    AU - Duncan, Francesca E.

    AU - Zelinski, Mary

    AU - Gunn, Alexander H.

    AU - Pahnke, Jennifer E.

    AU - O'Neill, Conor L.

    AU - Songsasen, Nucharin

    AU - Woodruff, Ryan I.

    AU - Woodruff, Teresa K.

    PY - 2016

    Y1 - 2016

    N2 - Primordial follicles dictate a female's reproductive life span and therefore are central to fertility preservation for both endangered species and individuals with fertility-threatening conditions. Ovarian tissue containing primordial follicles can be cryopreserved and later thawed and transplanted back into individuals to restore both endocrine function and fertility. Importantly, increasing numbers of human live births have been reported following ovarian tissue cryopreservation and transplantation. A current limitation of this technology is patient access to sites that are approved or equipped to process and cryopreserve ovarian tissue - especially in larger countries or low resource settings. Here, we review empirical evidence from both animal models and human studies that suggest that ovarian tissue can be transported at cold temperatures for several hours while still maintaining the integrity and reproductive potential of the primordial follicles within the tissue. In fact, several human live births have been reported in European countries using tissue that was transported at cold temperatures for up to 20 h before cryopreservation and transplantation. Ovarian tissue transport, if implemented widely in clinical practice, could therefore expand both patient and provider access to emerging fertility preservation options.

    AB - Primordial follicles dictate a female's reproductive life span and therefore are central to fertility preservation for both endangered species and individuals with fertility-threatening conditions. Ovarian tissue containing primordial follicles can be cryopreserved and later thawed and transplanted back into individuals to restore both endocrine function and fertility. Importantly, increasing numbers of human live births have been reported following ovarian tissue cryopreservation and transplantation. A current limitation of this technology is patient access to sites that are approved or equipped to process and cryopreserve ovarian tissue - especially in larger countries or low resource settings. Here, we review empirical evidence from both animal models and human studies that suggest that ovarian tissue can be transported at cold temperatures for several hours while still maintaining the integrity and reproductive potential of the primordial follicles within the tissue. In fact, several human live births have been reported in European countries using tissue that was transported at cold temperatures for up to 20 h before cryopreservation and transplantation. Ovarian tissue transport, if implemented widely in clinical practice, could therefore expand both patient and provider access to emerging fertility preservation options.

    UR - http://www.scopus.com/inward/record.url?scp=84998812067&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84998812067&partnerID=8YFLogxK

    U2 - 10.1530/REP-15-0598

    DO - 10.1530/REP-15-0598

    M3 - Review article

    C2 - 27492079

    AN - SCOPUS:84998812067

    VL - 152

    SP - R201-R210

    JO - Reproduction

    JF - Reproduction

    SN - 1470-1626

    IS - 6

    ER -