Ovarian steroids and serotonin neural function

Cynthia Bethea, M. Pecins-Thompson, W. E. Schutzer, C. Gundlah, Z. N. Lu

    Research output: Contribution to journalArticle

    153 Citations (Scopus)

    Abstract

    The serotonin neural system originates from ten nuclei in the mid- and hindbrain regions. The cells of the rostral nuclei project to almost every area of the forebrain, including the hypothalamus, limbic regions, basal ganglia, thalamic nuclei, and cortex. The caudal nuclei project to the spinal cord and interact with numerous autonomic and sensory systems. This article reviews much of the available literature from basic research and relevant clinical research that indicates that ovarian steroid hormones, estrogens and progestins, affect the function of the serotonin neural system. Experimental results in nonhuman primates from this laboratory are contrasted with studies in rodents and humans. The sites of action of ovarian hormones on the serotonin neural system include effects within serotonin neurons as well as effects on serotonin afferent neurons and serotonin target neurons. Therefore, information on estrogen and progestin receptor-containing neurons was synthesized with information on serotonin afferent and efferent circuits. The ability of estrogens and progestins to alter the function of the serotonin neural system at various levels provides a cellular mechanism whereby ovarian hormones can impact mood, cognition, pain, and numerous other autonomic functions.

    Original languageEnglish (US)
    Pages (from-to)87-123
    Number of pages37
    JournalMolecular Neurobiology
    Volume18
    Issue number2
    StatePublished - 1998

    Fingerprint

    Serotonin
    Steroids
    Hormones
    Progestins
    Neurons
    Estrogens
    Afferent Neurons
    Thalamic Nuclei
    Rhombencephalon
    Aptitude
    Progesterone Receptors
    Prosencephalon
    Mesencephalon
    Basal Ganglia
    Cell Nucleus
    Research
    Estrogen Receptors
    Cognition
    Primates
    Hypothalamus

    Keywords

    • Afferent circuits
    • Afferent neurons
    • Efferent circuits
    • Estrogen
    • Ovarian steroids
    • Progestin
    • Serotonin neural function
    • Target neurons

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Physiology

    Cite this

    Bethea, C., Pecins-Thompson, M., Schutzer, W. E., Gundlah, C., & Lu, Z. N. (1998). Ovarian steroids and serotonin neural function. Molecular Neurobiology, 18(2), 87-123.

    Ovarian steroids and serotonin neural function. / Bethea, Cynthia; Pecins-Thompson, M.; Schutzer, W. E.; Gundlah, C.; Lu, Z. N.

    In: Molecular Neurobiology, Vol. 18, No. 2, 1998, p. 87-123.

    Research output: Contribution to journalArticle

    Bethea, C, Pecins-Thompson, M, Schutzer, WE, Gundlah, C & Lu, ZN 1998, 'Ovarian steroids and serotonin neural function', Molecular Neurobiology, vol. 18, no. 2, pp. 87-123.
    Bethea C, Pecins-Thompson M, Schutzer WE, Gundlah C, Lu ZN. Ovarian steroids and serotonin neural function. Molecular Neurobiology. 1998;18(2):87-123.
    Bethea, Cynthia ; Pecins-Thompson, M. ; Schutzer, W. E. ; Gundlah, C. ; Lu, Z. N. / Ovarian steroids and serotonin neural function. In: Molecular Neurobiology. 1998 ; Vol. 18, No. 2. pp. 87-123.
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