Ovarian response in superovulated cycles after suppression with oral contraceptive steroids

Kenneth A. Burry, Laura H. Greenberg, Phillip E. Patton

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The endocrine response to controlled ovarian hyperstimulation was reviewed in 94 women undergoing in vitro fertilization during 114 cycles. The purpose of this review was to evaluate the effect of short-term oral contraceptive suppression on the recovery of pituitary gonadotropin function and subsequent controlled ovarian hyperstimulation. Seventy-three cycles (64%) were adequate for oocyte retrieval. In 41 cycles (36%) hyperstimulation was discontinued. The serum 17β-estradiol value in women with a poor response was 57 ± 50 pg/ml on day 8 compared with 376 ± 334 pg/ml in the women who completed in vitro fertilization (p < 0.05). The majority of women (84.2%) had a prompt response to controlled ovarian hyperstimulation after short-term oral contraceptive suppression. Most discontinuations were due to dominant follicle selection or luteinizing hormone surge and not to oversuppression by short-term oral contraceptives. Clinical pregnancies occurred in 15 women (20.5% of harvests).

Original languageEnglish (US)
Pages (from-to)1592-1596
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Volume164
Issue number6 PART 1
DOIs
StatePublished - Jun 1991

Keywords

  • Contraceptive suppression of gonadotropins
  • programmed ovarian hyperstimulation

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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