Ovarian follicle culture

Advances and challenges for human and nonhuman primates

Evelyn E. Telfer, Mary Zelinski

    Research output: Contribution to journalArticle

    119 Citations (Scopus)

    Abstract

    The removal and cryostorage of ovarian cortical biopsies is now offered as a fertility preservation option for young women. The only available option to restore fertility using this tissue is by transplantation, which may not be possible for all patients. The full potential of this tissue to restore fertility could be achieved by the development of in vitro systems that support oocyte development from the most immature stages to maturation. The techniques of in vitro growth (IVG) combined with in vitro maturation (IVM) are being developed with human tissue, but comparing different systems has been difficult because of the scarcity of tissue so nonhuman primates are being used as model systems. There are many challenges to developing a complete culture system that would support human oocyte development, and this review outlines the approaches being taken by several groups using tissue from women and nonhuman primate models to support each of the stages of oocyte development.

    Original languageEnglish (US)
    Pages (from-to)1523-1533
    Number of pages11
    JournalFertility and Sterility
    Volume99
    Issue number6
    DOIs
    StatePublished - May 2013

    Fingerprint

    Ovarian Follicle
    Primates
    Oocytes
    Fertility
    Fertility Preservation
    Tissue Transplantation
    Human Development
    Biopsy
    Growth
    In Vitro Techniques

    Keywords

    • Follicle culture
    • human oocytes
    • in vitro growth
    • primates
    • primordial follicle

    ASJC Scopus subject areas

    • Obstetrics and Gynecology
    • Reproductive Medicine

    Cite this

    Ovarian follicle culture : Advances and challenges for human and nonhuman primates. / Telfer, Evelyn E.; Zelinski, Mary.

    In: Fertility and Sterility, Vol. 99, No. 6, 05.2013, p. 1523-1533.

    Research output: Contribution to journalArticle

    @article{be86649a27544f25830edf68d99af072,
    title = "Ovarian follicle culture: Advances and challenges for human and nonhuman primates",
    abstract = "The removal and cryostorage of ovarian cortical biopsies is now offered as a fertility preservation option for young women. The only available option to restore fertility using this tissue is by transplantation, which may not be possible for all patients. The full potential of this tissue to restore fertility could be achieved by the development of in vitro systems that support oocyte development from the most immature stages to maturation. The techniques of in vitro growth (IVG) combined with in vitro maturation (IVM) are being developed with human tissue, but comparing different systems has been difficult because of the scarcity of tissue so nonhuman primates are being used as model systems. There are many challenges to developing a complete culture system that would support human oocyte development, and this review outlines the approaches being taken by several groups using tissue from women and nonhuman primate models to support each of the stages of oocyte development.",
    keywords = "Follicle culture, human oocytes, in vitro growth, primates, primordial follicle",
    author = "Telfer, {Evelyn E.} and Mary Zelinski",
    year = "2013",
    month = "5",
    doi = "10.1016/j.fertnstert.2013.03.043",
    language = "English (US)",
    volume = "99",
    pages = "1523--1533",
    journal = "Fertility and Sterility",
    issn = "0015-0282",
    publisher = "Elsevier Inc.",
    number = "6",

    }

    TY - JOUR

    T1 - Ovarian follicle culture

    T2 - Advances and challenges for human and nonhuman primates

    AU - Telfer, Evelyn E.

    AU - Zelinski, Mary

    PY - 2013/5

    Y1 - 2013/5

    N2 - The removal and cryostorage of ovarian cortical biopsies is now offered as a fertility preservation option for young women. The only available option to restore fertility using this tissue is by transplantation, which may not be possible for all patients. The full potential of this tissue to restore fertility could be achieved by the development of in vitro systems that support oocyte development from the most immature stages to maturation. The techniques of in vitro growth (IVG) combined with in vitro maturation (IVM) are being developed with human tissue, but comparing different systems has been difficult because of the scarcity of tissue so nonhuman primates are being used as model systems. There are many challenges to developing a complete culture system that would support human oocyte development, and this review outlines the approaches being taken by several groups using tissue from women and nonhuman primate models to support each of the stages of oocyte development.

    AB - The removal and cryostorage of ovarian cortical biopsies is now offered as a fertility preservation option for young women. The only available option to restore fertility using this tissue is by transplantation, which may not be possible for all patients. The full potential of this tissue to restore fertility could be achieved by the development of in vitro systems that support oocyte development from the most immature stages to maturation. The techniques of in vitro growth (IVG) combined with in vitro maturation (IVM) are being developed with human tissue, but comparing different systems has been difficult because of the scarcity of tissue so nonhuman primates are being used as model systems. There are many challenges to developing a complete culture system that would support human oocyte development, and this review outlines the approaches being taken by several groups using tissue from women and nonhuman primate models to support each of the stages of oocyte development.

    KW - Follicle culture

    KW - human oocytes

    KW - in vitro growth

    KW - primates

    KW - primordial follicle

    UR - http://www.scopus.com/inward/record.url?scp=84876998390&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84876998390&partnerID=8YFLogxK

    U2 - 10.1016/j.fertnstert.2013.03.043

    DO - 10.1016/j.fertnstert.2013.03.043

    M3 - Article

    VL - 99

    SP - 1523

    EP - 1533

    JO - Fertility and Sterility

    JF - Fertility and Sterility

    SN - 0015-0282

    IS - 6

    ER -