Outcomes of intraoperative radiotherapy for early-stage breast cancer: Experience from a multidisciplinary breast oncology program

Shushan Rana, Arpana Naik, Susha Pillai, John Vetto, Rodney Pommier, Charlotte Dai Kubicky

    Research output: Contribution to journalArticle

    Abstract

    Background: Intraoperative radiotherapy (IORT) was implemented at our institution for early stage breast cancer patients including those with geographic or medical co-morbidity limitations to whole breast radiation therapy (WBRT). Methods: Retrospective review of patients (n = 127) who underwent IORT from 2009 to 2016 for breast cancer. Demographics, pathology, toxicity, and recurrences were ascertained. Results: The median age was 67 years (interquartile range: 62–73). At median follow-up (49.6 months), 5 patients (4%) had ipsilateral breast tumor recurrence with median time to recurrence of 36.8 months. Acute and late grade ≥3 skin toxicities were observed in 3.1% and 4.7% of patients, respectively. A subset (n = 7) who received prior ipsilateral WBRT was found to have no subsequent local recurrence, one case of acute grade 3 skin toxicity, and no late toxicity. Conclusions: IORT is a safe and effective alternative to whole breast radiotherapy, and serves as a suitable alternative to completion mastectomy in locally recurrent breast cancer.

    Original languageEnglish (US)
    JournalAmerican journal of surgery
    DOIs
    StatePublished - Jan 1 2019

    Fingerprint

    Breast
    Radiotherapy
    Breast Neoplasms
    Recurrence
    Skin
    Mastectomy
    Demography
    Pathology
    Morbidity

    ASJC Scopus subject areas

    • Surgery

    Cite this

    @article{7808ccac56394ee687cc8b26b4de6e36,
    title = "Outcomes of intraoperative radiotherapy for early-stage breast cancer: Experience from a multidisciplinary breast oncology program",
    abstract = "Background: Intraoperative radiotherapy (IORT) was implemented at our institution for early stage breast cancer patients including those with geographic or medical co-morbidity limitations to whole breast radiation therapy (WBRT). Methods: Retrospective review of patients (n = 127) who underwent IORT from 2009 to 2016 for breast cancer. Demographics, pathology, toxicity, and recurrences were ascertained. Results: The median age was 67 years (interquartile range: 62–73). At median follow-up (49.6 months), 5 patients (4{\%}) had ipsilateral breast tumor recurrence with median time to recurrence of 36.8 months. Acute and late grade ≥3 skin toxicities were observed in 3.1{\%} and 4.7{\%} of patients, respectively. A subset (n = 7) who received prior ipsilateral WBRT was found to have no subsequent local recurrence, one case of acute grade 3 skin toxicity, and no late toxicity. Conclusions: IORT is a safe and effective alternative to whole breast radiotherapy, and serves as a suitable alternative to completion mastectomy in locally recurrent breast cancer.",
    author = "Shushan Rana and Arpana Naik and Susha Pillai and John Vetto and Rodney Pommier and Kubicky, {Charlotte Dai}",
    year = "2019",
    month = "1",
    day = "1",
    doi = "10.1016/j.amjsurg.2019.06.014",
    language = "English (US)",
    journal = "American Journal of Surgery",
    issn = "0002-9610",
    publisher = "Elsevier Inc.",

    }

    TY - JOUR

    T1 - Outcomes of intraoperative radiotherapy for early-stage breast cancer

    T2 - Experience from a multidisciplinary breast oncology program

    AU - Rana, Shushan

    AU - Naik, Arpana

    AU - Pillai, Susha

    AU - Vetto, John

    AU - Pommier, Rodney

    AU - Kubicky, Charlotte Dai

    PY - 2019/1/1

    Y1 - 2019/1/1

    N2 - Background: Intraoperative radiotherapy (IORT) was implemented at our institution for early stage breast cancer patients including those with geographic or medical co-morbidity limitations to whole breast radiation therapy (WBRT). Methods: Retrospective review of patients (n = 127) who underwent IORT from 2009 to 2016 for breast cancer. Demographics, pathology, toxicity, and recurrences were ascertained. Results: The median age was 67 years (interquartile range: 62–73). At median follow-up (49.6 months), 5 patients (4%) had ipsilateral breast tumor recurrence with median time to recurrence of 36.8 months. Acute and late grade ≥3 skin toxicities were observed in 3.1% and 4.7% of patients, respectively. A subset (n = 7) who received prior ipsilateral WBRT was found to have no subsequent local recurrence, one case of acute grade 3 skin toxicity, and no late toxicity. Conclusions: IORT is a safe and effective alternative to whole breast radiotherapy, and serves as a suitable alternative to completion mastectomy in locally recurrent breast cancer.

    AB - Background: Intraoperative radiotherapy (IORT) was implemented at our institution for early stage breast cancer patients including those with geographic or medical co-morbidity limitations to whole breast radiation therapy (WBRT). Methods: Retrospective review of patients (n = 127) who underwent IORT from 2009 to 2016 for breast cancer. Demographics, pathology, toxicity, and recurrences were ascertained. Results: The median age was 67 years (interquartile range: 62–73). At median follow-up (49.6 months), 5 patients (4%) had ipsilateral breast tumor recurrence with median time to recurrence of 36.8 months. Acute and late grade ≥3 skin toxicities were observed in 3.1% and 4.7% of patients, respectively. A subset (n = 7) who received prior ipsilateral WBRT was found to have no subsequent local recurrence, one case of acute grade 3 skin toxicity, and no late toxicity. Conclusions: IORT is a safe and effective alternative to whole breast radiotherapy, and serves as a suitable alternative to completion mastectomy in locally recurrent breast cancer.

    UR - http://www.scopus.com/inward/record.url?scp=85067669369&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85067669369&partnerID=8YFLogxK

    U2 - 10.1016/j.amjsurg.2019.06.014

    DO - 10.1016/j.amjsurg.2019.06.014

    M3 - Article

    AN - SCOPUS:85067669369

    JO - American Journal of Surgery

    JF - American Journal of Surgery

    SN - 0002-9610

    ER -