Outcomes of intraoperative radiotherapy for early-stage breast cancer: Experience from a multidisciplinary breast oncology program

Shushan Rana, Arpana Naik, Susha Pillai, John Vetto, Rodney Pommier, Charlotte Dai Kubicky

    Research output: Contribution to journalArticle


    Background: Intraoperative radiotherapy (IORT) was implemented at our institution for early stage breast cancer patients including those with geographic or medical co-morbidity limitations to whole breast radiation therapy (WBRT). Methods: Retrospective review of patients (n = 127) who underwent IORT from 2009 to 2016 for breast cancer. Demographics, pathology, toxicity, and recurrences were ascertained. Results: The median age was 67 years (interquartile range: 62–73). At median follow-up (49.6 months), 5 patients (4%) had ipsilateral breast tumor recurrence with median time to recurrence of 36.8 months. Acute and late grade ≥3 skin toxicities were observed in 3.1% and 4.7% of patients, respectively. A subset (n = 7) who received prior ipsilateral WBRT was found to have no subsequent local recurrence, one case of acute grade 3 skin toxicity, and no late toxicity. Conclusions: IORT is a safe and effective alternative to whole breast radiotherapy, and serves as a suitable alternative to completion mastectomy in locally recurrent breast cancer.

    Original languageEnglish (US)
    Pages (from-to)655-659
    Number of pages5
    JournalAmerican journal of surgery
    Issue number4
    StatePublished - Apr 2020


    ASJC Scopus subject areas

    • Surgery

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