Outcomes of Acute Myocardial Infarction in Heart Transplant Recipients

Tariq Enezate, Jad Omran, Patricia P. Chang, Mitul Patel, Christopher Chien, Raymond R. Bacon, Eric Adler

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Heart transplantation (HT) recipients represent a growing patient population. Although mechanisms might differ, coronary artery disease is an important cause of morbidity in this group. Limited data are available on the outcomes of acute myocardial infarction (AMI) in HT in comparison to general population (non-HT). The study population was extracted from the National Readmissions Data 2014 using International Classification of Diseases, Ninth Revision, Clinical Modification codes for AMI and HT. The study outcomes included in-hospital all-cause mortality, length of hospital stay (LOS), cardiogenic shock, acute kidney injury, the likelihood of receiving invasive left-sided cardiac catheterization with and/or without percutaneous coronary intervention (PCI) and 30-day readmission rates. A total of 259,794 discharges with a principal diagnosis of AMI were identified, in which 789 had a history of HT. In comparison to non-HT, HT group was associated with longer LOS (5.9 vs 4.9 days, p <0.01), more cardiogenic shock (8.8% vs 6.4%, p <0.01), more acute kidney injury (26.2% vs 17.6%, p <0.01), less catheterization (59.7% vs 75.1%, p <0.01), less use of PCI (35.2% vs 50.0%, p <0.01), and higher 30-day readmission rate (21.3% vs 14.4%, p <0.01). However, there was no statistically significant difference in all-cause mortality (6.8% vs 5.4%, p = 0.07). In conclusion, compared with non-HT, HT with AMI was associated with longer LOS, more in-hospital morbidity, lower likelihood of receiving invasive treatment (including PCI), and higher 30-day readmission rates. There was no significant difference in all-cause mortality.

Original languageEnglish (US)
Pages (from-to)2080-2085
Number of pages6
JournalAmerican Journal of Cardiology
Volume122
Issue number12
DOIs
StatePublished - Dec 15 2018
Externally publishedYes

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Heart Transplantation
Length of Stay
Myocardial Infarction
Percutaneous Coronary Intervention
Cardiogenic Shock
Transplantation
Acute Kidney Injury
Mortality
Population
Morbidity
International Classification of Diseases
Cardiac Catheterization
Catheterization
Transplant Recipients
Coronary Artery Disease
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Enezate, T., Omran, J., P. Chang, P., Patel, M., Chien, C., Bacon, R. R., & Adler, E. (2018). Outcomes of Acute Myocardial Infarction in Heart Transplant Recipients. American Journal of Cardiology, 122(12), 2080-2085. https://doi.org/10.1016/j.amjcard.2018.08.060

Outcomes of Acute Myocardial Infarction in Heart Transplant Recipients. / Enezate, Tariq; Omran, Jad; P. Chang, Patricia; Patel, Mitul; Chien, Christopher; Bacon, Raymond R.; Adler, Eric.

In: American Journal of Cardiology, Vol. 122, No. 12, 15.12.2018, p. 2080-2085.

Research output: Contribution to journalArticle

Enezate, T, Omran, J, P. Chang, P, Patel, M, Chien, C, Bacon, RR & Adler, E 2018, 'Outcomes of Acute Myocardial Infarction in Heart Transplant Recipients', American Journal of Cardiology, vol. 122, no. 12, pp. 2080-2085. https://doi.org/10.1016/j.amjcard.2018.08.060
Enezate T, Omran J, P. Chang P, Patel M, Chien C, Bacon RR et al. Outcomes of Acute Myocardial Infarction in Heart Transplant Recipients. American Journal of Cardiology. 2018 Dec 15;122(12):2080-2085. https://doi.org/10.1016/j.amjcard.2018.08.060
Enezate, Tariq ; Omran, Jad ; P. Chang, Patricia ; Patel, Mitul ; Chien, Christopher ; Bacon, Raymond R. ; Adler, Eric. / Outcomes of Acute Myocardial Infarction in Heart Transplant Recipients. In: American Journal of Cardiology. 2018 ; Vol. 122, No. 12. pp. 2080-2085.
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abstract = "Heart transplantation (HT) recipients represent a growing patient population. Although mechanisms might differ, coronary artery disease is an important cause of morbidity in this group. Limited data are available on the outcomes of acute myocardial infarction (AMI) in HT in comparison to general population (non-HT). The study population was extracted from the National Readmissions Data 2014 using International Classification of Diseases, Ninth Revision, Clinical Modification codes for AMI and HT. The study outcomes included in-hospital all-cause mortality, length of hospital stay (LOS), cardiogenic shock, acute kidney injury, the likelihood of receiving invasive left-sided cardiac catheterization with and/or without percutaneous coronary intervention (PCI) and 30-day readmission rates. A total of 259,794 discharges with a principal diagnosis of AMI were identified, in which 789 had a history of HT. In comparison to non-HT, HT group was associated with longer LOS (5.9 vs 4.9 days, p <0.01), more cardiogenic shock (8.8{\%} vs 6.4{\%}, p <0.01), more acute kidney injury (26.2{\%} vs 17.6{\%}, p <0.01), less catheterization (59.7{\%} vs 75.1{\%}, p <0.01), less use of PCI (35.2{\%} vs 50.0{\%}, p <0.01), and higher 30-day readmission rate (21.3{\%} vs 14.4{\%}, p <0.01). However, there was no statistically significant difference in all-cause mortality (6.8{\%} vs 5.4{\%}, p = 0.07). In conclusion, compared with non-HT, HT with AMI was associated with longer LOS, more in-hospital morbidity, lower likelihood of receiving invasive treatment (including PCI), and higher 30-day readmission rates. There was no significant difference in all-cause mortality.",
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