Abstract
Background There is a paucity of outcomes data for patients with lymph node metastasis from cutaneous squamous cell carcinoma of head and neck (SCCHN). Methods Patients from a tertiary care center with cutaneous SCCHN metastatic to parotid and or cervical lymph nodes were identified. Data were abstracted and analyzed using COX multivariate analysis. Results Fifty-one patients (47 men, and 4 women) with a median age of 73 years were identified. Eight patients (16%) had recurrent disease and 11 (22%) were immunosuppressed. Forty patients (71%) received adjuvant radiation therapy. Median overall survival was 23 months (range, 3-148 months). Recurrent disease was associated with higher risk of death (hazard ratio [HR], 2.7; 95% confidence interval [CI] 1.1-6.9) and radiation therapy with reduced risk (HR, 0.18; 95% CI, 0.06-0.54). Conclusion Lymph node metastases from cutaneous SCCHN is associated with poor survival. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
Original language | English (US) |
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Pages (from-to) | 999-1004 |
Number of pages | 6 |
Journal | Head and Neck |
Volume | 33 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2011 |
Keywords
- cervical metastasis
- head and neck
- skin cancer
- squamous cell carcinoma
- survival
ASJC Scopus subject areas
- Otorhinolaryngology