Outcome of patients treated surgically for lymph node metastases from cutaneous squamous cell carcinoma of the head and neck

Babak Givi, Peter E. Andersen, Brian S. Diggs, Mark K. Wax, Neil D. Gross

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Background There is a paucity of outcomes data for patients with lymph node metastasis from cutaneous squamous cell carcinoma of head and neck (SCCHN). Methods Patients from a tertiary care center with cutaneous SCCHN metastatic to parotid and or cervical lymph nodes were identified. Data were abstracted and analyzed using COX multivariate analysis. Results Fifty-one patients (47 men, and 4 women) with a median age of 73 years were identified. Eight patients (16%) had recurrent disease and 11 (22%) were immunosuppressed. Forty patients (71%) received adjuvant radiation therapy. Median overall survival was 23 months (range, 3-148 months). Recurrent disease was associated with higher risk of death (hazard ratio [HR], 2.7; 95% confidence interval [CI] 1.1-6.9) and radiation therapy with reduced risk (HR, 0.18; 95% CI, 0.06-0.54). Conclusion Lymph node metastases from cutaneous SCCHN is associated with poor survival. © 2011 Wiley Periodicals, Inc. Head Neck, 2011

Original languageEnglish (US)
Pages (from-to)999-1004
Number of pages6
JournalHead and Neck
Volume33
Issue number7
DOIs
StatePublished - Jul 1 2011

Keywords

  • cervical metastasis
  • head and neck
  • skin cancer
  • squamous cell carcinoma
  • survival

ASJC Scopus subject areas

  • Otorhinolaryngology

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