Osteoporosis in men: What is similar and what is different?

Michaël R. Laurent, Evelien Gielen, Eric Orwoll, Dirk Vanderschueren

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Male gender is a protective factor against the development of osteoporosis but men face a higher refracture risk, higher mortality risk, and a higher treatment gap. Consequently, men contribute considerably to the disease burden of osteoporosis. This chapter aims to review recent advances in our understanding of the epidemiology of male osteoporosis, the reasons why osteoporosis and fractures are less common in men, how sex steroids (androgens and estrogens) and other factors regulate male bone metabolism and contribute to skeletal sexual dimorphism, as well as the diagnosis and treatment of male osteoporosis. We focus on similarities and differences in men versus women. Our work aims to contribute to the understanding of male osteoporosis as a condition that is much more similar than different from osteoporosis in postmenopausal women.

Original languageEnglish (US)
Title of host publicationMarcus and Feldman’s Osteoporosis
PublisherElsevier
Pages589-632
Number of pages44
ISBN (Electronic)9780128130735
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

Keywords

  • Androgens
  • Bone mineral density
  • Cortical bone
  • Epidemiology
  • Estrogens
  • Fractures
  • Male osteoporosis
  • Peak bone mass

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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