Abstract
Male gender is a protective factor against the development of osteoporosis but men face a higher refracture risk, higher mortality risk, and a higher treatment gap. Consequently, men contribute considerably to the disease burden of osteoporosis. This chapter aims to review recent advances in our understanding of the epidemiology of male osteoporosis, the reasons why osteoporosis and fractures are less common in men, how sex steroids (androgens and estrogens) and other factors regulate male bone metabolism and contribute to skeletal sexual dimorphism, as well as the diagnosis and treatment of male osteoporosis. We focus on similarities and differences in men versus women. Our work aims to contribute to the understanding of male osteoporosis as a condition that is much more similar than different from osteoporosis in postmenopausal women.
Original language | English (US) |
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Title of host publication | Marcus and Feldman’s Osteoporosis |
Publisher | Elsevier |
Pages | 589-632 |
Number of pages | 44 |
ISBN (Electronic) | 9780128130735 |
DOIs | |
State | Published - Jan 1 2020 |
Keywords
- Androgens
- Bone mineral density
- Cortical bone
- Epidemiology
- Estrogens
- Fractures
- Male osteoporosis
- Peak bone mass
ASJC Scopus subject areas
- General Agricultural and Biological Sciences
- General Biochemistry, Genetics and Molecular Biology
- General Medicine